Cerebral White Matter and Cognition in Hydrocephalic Children

Brain mechanisms for reading and language processing in spina bifida meningomyelocele: A combined magnetic source- and structural magnetic resonance imaging study.

“…Our findings are generally consistent with earlier in vivo anatomical studies of SBM (Fletcher et al, 1992; 1996; 2005; Hasan et al., 2008; Juranek et al, 2008) revealing a posterior-to-anterior gradient in the severity of brain impairment and provide additional data regarding the type of compensatory mechanisms at the neuronal level ensuring adequate development of word-level reading skills. Early disruption of brain development, that begins in utero in children with SBM, is followed later in development by further abnormalities.…”

Brain mechanisms for reading and language processing in spina bifida meningomyelocele: A combined magnetic source- and structural magnetic resonance imaging study.

“…Our findings are generally consistent with earlier in vivo anatomical studies of SBM (Fletcher et al, 1992; 1996; 2005; Hasan et al., 2008; Juranek et al, 2008) revealing a posterior-to-anterior gradient in the severity of brain impairment and provide additional data regarding the type of compensatory mechanisms at the neuronal level ensuring adequate development of word-level reading skills. Early disruption of brain development, that begins in utero in children with SBM, is followed later in development by further abnormalities.…”

Structure, Integrity, and Function of the Hypoplastic Corpus Callosum in Spina Bifida Myelomeningocele

“…IQ correlated positively with the volume of the entire CC, and regionally with the anterior and posterior CC. IQ decreased with volume decreases in the genu and splenium fibers of the CC, a finding consistent with previous research where measures of IQ positively correlated with area measures of the entire CC in SBM (Fletcher et al, 1992, 1996).…”

Impact of ventricle size on neuropsychological outcomes in treated pediatric hydrocephalus: an HCRN prospective cohort study

“…In context, these findings are consistent with previous work in the Ugandan myelomeningocele population 17 and the North American aqueductal stenosis setting. 6 However, the current study contradicts findings from a smaller, retrospective study 7 and another representing adult patients with normal pressure hydrocephalus. 18 Our study also differs from diffusion tensor imaging studies (a proxy for functional outcomes) which have shown that a larger treated ventricle size correlated with poorer outcomes in the premature IVH hydrocephalus population.…”

Brain mechanisms for reading and language processing in spina bifida meningomyelocele: A combined magnetic source- and structural magnetic resonance imaging study.

“…Our findings are generally consistent with earlier in vivo anatomical studies of SBM (Fletcher et al, 1992; 1996; 2005; Hasan et al., 2008; Juranek et al, 2008) revealing a posterior-to-anterior gradient in the severity of brain impairment and provide additional data regarding the type of compensatory mechanisms at the neuronal level ensuring adequate development of word-level reading skills. Early disruption of brain development, that begins in utero in children with SBM, is followed later in development by further abnormalities.…”

Structure, Integrity, and Function of the Hypoplastic Corpus Callosum in Spina Bifida Myelomeningocele

“…IQ correlated positively with the volume of the entire CC, and regionally with the anterior and posterior CC. IQ decreased with volume decreases in the genu and splenium fibers of the CC, a finding consistent with previous research where measures of IQ positively correlated with area measures of the entire CC in SBM (Fletcher et al, 1992, 1996).…”

Impact of ventricle size on neuropsychological outcomes in treated pediatric hydrocephalus: an HCRN prospective cohort study

“…In context, these findings are consistent with previous work in the Ugandan myelomeningocele population 17 and the North American aqueductal stenosis setting. 6 However, the current study contradicts findings from a smaller, retrospective study 7 and another representing adult patients with normal pressure hydrocephalus. 18 Our study also differs from diffusion tensor imaging studies (a proxy for functional outcomes) which have shown that a larger treated ventricle size correlated with poorer outcomes in the premature IVH hydrocephalus population.…”

Brain mechanisms for reading and language processing in spina bifida meningomyelocele: A combined magnetic source- and structural magnetic resonance imaging study.

“…Our findings are generally consistent with earlier in vivo anatomical studies of SBM (Fletcher et al, 1992; 1996; 2005; Hasan et al., 2008; Juranek et al, 2008) revealing a posterior-to-anterior gradient in the severity of brain impairment and provide additional data regarding the type of compensatory mechanisms at the neuronal level ensuring adequate development of word-level reading skills. Early disruption of brain development, that begins in utero in children with SBM, is followed later in development by further abnormalities.…”

Structure, Integrity, and Function of the Hypoplastic Corpus Callosum in Spina Bifida Myelomeningocele

“…IQ correlated positively with the volume of the entire CC, and regionally with the anterior and posterior CC. IQ decreased with volume decreases in the genu and splenium fibers of the CC, a finding consistent with previous research where measures of IQ positively correlated with area measures of the entire CC in SBM (Fletcher et al, 1992, 1996).…”

Impact of ventricle size on neuropsychological outcomes in treated pediatric hydrocephalus: an HCRN prospective cohort study

“…In context, these findings are consistent with previous work in the Ugandan myelomeningocele population 17 and the North American aqueductal stenosis setting. 6 However, the current study contradicts findings from a smaller, retrospective study 7 and another representing adult patients with normal pressure hydrocephalus. 18 Our study also differs from diffusion tensor imaging studies (a proxy for functional outcomes) which have shown that a larger treated ventricle size correlated with poorer outcomes in the premature IVH hydrocephalus population.…”