2021
DOI: 10.18632/aging.203557
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Abstract: Introduction: Cerebral small vessel disease (SVD) is prevalent in the elderly population and is associated with increased risk of dementia, stroke and disability. Currently there are no clear targets or strategies for the treatment of cerebral SVD. We set out to identify modifiable vascular treatment targets. Patients and Methods: 112 participants with and without a history of CVD underwent macrovascular, microvascular and endothelial function tests and an MRI head scan. Results: Increase… Show more

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Cited by 9 publications
(6 citation statements)
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“…A recently published study focused on that relationship pointed out that augmented carotid intima-media thickness and carotidfemoral pulse-wave velocity are parameters that indicate the presence of cerebral whitematter hyperintensities. Moreover, it seems interesting that the adjusted cerebral-resistance index and brachial flow-mediated dilation time to peak were linked with the severity of cerebral white-matter alteration; the ongoing altered white matter is independent of age and gender [112]. At the same time, when producing post-occlusive reactive hyperemia, this parameter could be considered a target of microvascular reactivity.…”
Section: Diagnosis Of Cmd and Brain Svdmentioning
confidence: 99%
See 1 more Smart Citation
“…A recently published study focused on that relationship pointed out that augmented carotid intima-media thickness and carotidfemoral pulse-wave velocity are parameters that indicate the presence of cerebral whitematter hyperintensities. Moreover, it seems interesting that the adjusted cerebral-resistance index and brachial flow-mediated dilation time to peak were linked with the severity of cerebral white-matter alteration; the ongoing altered white matter is independent of age and gender [112]. At the same time, when producing post-occlusive reactive hyperemia, this parameter could be considered a target of microvascular reactivity.…”
Section: Diagnosis Of Cmd and Brain Svdmentioning
confidence: 99%
“…At the same time, when producing post-occlusive reactive hyperemia, this parameter could be considered a target of microvascular reactivity. Time of post-occlusive hyperemia is related to the expansion, and the severity of white-matter alterations, together with ankle Brachial Pressure Index and urinary albumin excretion rate [112].…”
Section: Diagnosis Of Cmd and Brain Svdmentioning
confidence: 99%
“…The ECG-gated carotid and femoral pulses were recorded sequentially by trained personnel using a Sphyg-moCor device (ver 8.2; AtCor Medical, Sydney, New South Wales, Australia), as described previously [16]. The recording was repeated three times and the average of those recordings was used for statistical analysis [16,19]. The time difference (in milliseconds) between the R-wave of the ECG and foot of the carotid and femoral pulse waves were calculated using the intersecting tangent algorithm.…”
Section: Determination Of Path Length and Calculation Of Carotid-femo...mentioning
confidence: 99%
“…Age, hypertension, atherosclerosis, cerebral amyloid vascular disease, genetic disorders, and other factors are recognized as risk factors (Elyas et al, 2021). The autonomic nervous system, which innervates all organs of the human body, plays a crucial role in regulating the body's response to various stressors, such as hypertension, hyperglycemia, acute ischemic stroke, and cerebral microangiopathy.…”
Section: Introductionmentioning
confidence: 99%