volume 26, issue 3, P457-466 2011
DOI: 10.3233/jad-2011-110056
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Karine Madsen, Wolf-Julian Neumann, Klaus Holst, Lisbeth Marner, Mette Thorlund Haahr, Szabolcs Lehel, Gitte Moos Knudsen, Steen Gregers Hasselbalch

Abstract: The 5-HT4 receptor may play a role in memory and learning and 5-HT4 receptor activation has been suggested to modulate acetylcholine release and to reduce amyloid-β (Aβ) accumulation. The aim of this study was for the first time to investigate the in vivo cerebral 5-HT4 receptor binding in early Alzheimer disease (AD) patients in relation to cortical Aβ burden. Eleven newly diagnosed untreated AD patients (mean MMSE 24, range 19-27) and twelve age- and gender-matched healthy controls underwent a two-hour dynam…

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