Cerebral Salt Wasting in Children

Fludrocortisone Treatment in a Child with Severe Cerebral Salt Wasting

“…In the literature, there are controversial results regarding the effect of mineralocorticoid replacement in CSW. Some authors have reported beneficial effects of mineralocorticoid replacement in CSW [8, 9], whereas others have not [5, 6]. In our patient, the successful correction of natriuresis, hyponatremia and excessive urine output with fludrocortisone therapy suggested that in patients with severe CSW, this choice of treatment can be beneficial.…”

Clinical predictors of treatment outcome in Melanesian adults with Tuberculous Meningitis at the Kundiawa General Hospital in Papua New Guinea

“…A positive fluid balance 24-hours after admission should also alert clinicians to possible onset or progression of acute renal insufficiency to failure which will inadvertently contribute to increased mortality. Raised intracranial pressure from an infectious brain insult like TB Meningitis may also induce syndromes of salt wasting or excess anti-diuretic hormone action (SIADH) with resulting hyponatremia and fluid depletion or repletion respectively, which may in turn entail functional neurological derangement with poor outcomes [24][25][26][27] .…”

Cerebral salt wasting after traumatic brain injury: a review of the literature

“…Nine (60 %) of the publications were case reports that presented a total of 10 cases, five (33 %) were prospective and 1 (7 %) was a retrospective study. Seven of the fifteen (47 %) articles were published in a neurology or neurosurgery journal [ 11 – 17 ], six (40 %) were in a pediatric journal [ 17 – 22 ] and the remainder were published within journals of varied specialties [ 23 – 25 ].…”

“…Patient population was inconsistently defined across cohort studies (Additional files 1 and 2 ). Five of the 9 case reports (56 %) were from American institutions [ 16 , 17 , 21 , 22 , 25 ]. The remaining case reports and cohort studies were conducted worldwide.…”

“…Of the six cohort studies, one study was conducted in pediatric patients [ 18 ], one study included patients aged ≥20 years [ 11 ], and the remaining four studies did not mention specific age requirements and included patients ranging from 0 – 92 years old [ 12 – 14 , 23 ]. Eight of the 10 presented cases were of patients under the age of 18 [ 17 , 19 – 22 , 24 , 25 ]. One study examined a population of severely injured patients, defined as those with brain injury and a Glasgow Coma Score (GCS) less than 9 [ 12 ].…”