Cerebral Metabolic Dysfunction and Impaired Vigilance in Recently Abstinent Methamphetamine Abusers

London, Edythe D.; Berman, Steven M.; Voytek, Bradley; Simon, Sara L.; Mandelkern, M.; Monterosso, John; Thompson, Paul M.; Brody, Arthur L.; Geaga, Jennifer A.; Hong, Michael; Hayashi, Kiralee M.; Rawson, Richard A.; Ling, Walter

doi:10.1016/j.biopsych.2005.04.039

Cited by 124 publications

(125 citation statements)

References 53 publications

(74 reference statements)

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“…In the absence of neuroimaging results we cannot rule out this explanation, however, given the similarities between the current sample and Kaufman et al (2003), in terms of both lifetime and recent cocaine use behavior, as well as demographic characteristics, there appears to be no direct evidence to support this hypothesis. In addition, ACC hypoactivity appears to be a general feature of drug abusers, with findings in opiate (Forman et al, 2004), cannabis (Gruber and Yurgelun-Todd, 2005), and methamphetamine (London et al, 2005) samples. Furthermore, this sample does show impairment in other ACC-related cognitive functions, such as inhibitory control and error awareness.…”

Section: Post-error Adaptationmentioning

confidence: 95%

Post-Error Behavior in Active Cocaine Users: Poor Awareness of Errors in the Presence of Intact Performance Adjustments

Hester

Simões‐Franklin

Garavan

2007

Neuropsychopharmacol

107

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Active cocaine abusers have a diminished neural response to errors, particularly in the anterior cingulate cortex thought critical to error processing. The inability to detect, or adjust performance following errors has been linked to clinical symptoms including the loss of insight and perseverative behavior. We investigated the cognitive implications of this diminished error-related activity, using response inhibition tasks that required error awareness and performance adaptation. Twenty-one active cocaine users (six female subjects, mean age ¼ 40.3) and 22 non-drug using adults (six female subjects, mean ¼ 39.9) participated. The results indicated that cocaine users consistently demonstrated poorer inhibitory control, a deficit accompanied by reduced awareness of errors. Adaptation of post-error reaction times did not differ between groups, although a different measure of adaptive behavior: exerting inhibitory control on the trial immediately after failing to inhibit, was significantly poorer in the cocaine using sample. In summary, cocaine users demonstrated a diminished capacity for monitoring their behavior, but were able to perform post-error adjustment to processes not already suffering an underlying deficit. These difficulties are consistent with previous reports of cocaine-related hypoactivity in the neural system underlying cognitive control, and highlight the potential for cognitive dysfunction to manifest as behavioral deficits that likely contribute to the maintenance of drug dependence.

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Section: Post-error Adaptationmentioning

confidence: 95%

Post-Error Behavior in Active Cocaine Users: Poor Awareness of Errors in the Presence of Intact Performance Adjustments

Hester

Simões‐Franklin

Garavan

2007

Neuropsychopharmacol

107

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“…Neuroimaging studies have identified an association between these executive control deficits and dysfunction in prefrontal (particularly dorsolateral and inferior frontal), anterior cingulate, and orbitofrontal regions (Bolla et al 2001(Bolla et al , 2003(Bolla et al , 2004Goldstein et al 2001;Franklin et al 2002;Paulus et al 2002;Kaufman et al 2003;Hester and Garavan 2004;Gruber and Yurgelun-Todd 2005;London et al 2005;Tapert et al 2007;Paulus et al 2008). Individual studies have also identified changes within subcortical (thalamus and basal ganglia), parietal, temporal, and cerebellar regions, although these findings are less consistent.…”

Section: Executive Control Dysfunction In Addicted Drug Usersmentioning

confidence: 99%

The Role of Executive Control in Human Drug Addiction

Hester

Lubman

Yücel

2009

Current Topics in Behavioral Neurosciences

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“…1 Cingulate and insular dysfunctions may also contribute to impaired vigilance in MA-dependent subjects who recently stopped taking the drug. 6 Anterior cingulate dysfunction has also been observed in subjects who maintained abstinence from MA. Deficiencies were seen in activation during performance of a decision-making task after 1 month of abstinence.…”

Section: Introductionmentioning

confidence: 99%

Changes in cerebral glucose metabolism during early abstinence from chronic methamphetamine abuse

et al. 2007

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Changes in brain function during the initial weeks of abstinence from chronic methamphetamine abuse may substantially affect clinical outcome, but are not well understood. We used positron emission tomography with [F-18]fluorodeoxyglucose (FDG) to quantify regional cerebral glucose metabolism, an index of brain function, during performance of a vigilance task. A total of 10 methamphetamine-dependent subjects were tested after 5-9 days of abstinence, and after 4 additional weeks of supervised abstinence. A total of 12 healthy control subjects were tested at corresponding times. Global glucose metabolism increased between tests (P = 0.01), more in methamphetamine-dependent (10.9%, P = 0.02) than control subjects (1.9%, NS). Glucose metabolism did not change in subcortical regions of methamphetaminedependent subjects, but increased in neocortex, with maximal increase ( > 20%) in parietal regions. Changes in reaction time and self-reports of negative affect varied more in methamphetamine-dependent than in control subjects, and correlated both with the increase in parietal glucose metabolism, and decrease in relative activity (after scaling to the global mean) in some regions. A robust relationship between change in self-reports of depressive symptoms and relative activity in the ventral striatum may have great relevance to treatment success because of the role of this region in drug abuse-related behaviors. Shifts in corticalsubcortical metabolic balance either reflect new processes that occur during early abstinence, or the unmasking of effects of chronic methamphetamine abuse that are obscured by suppression of cortical glucose metabolism that continues for at least 5-9 days after cessation of methamphetamine self-administration.

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Cerebral Metabolic Dysfunction and Impaired Vigilance in Recently Abstinent Methamphetamine Abusers

Cited by 124 publications

References 53 publications

Post-Error Behavior in Active Cocaine Users: Poor Awareness of Errors in the Presence of Intact Performance Adjustments

Post-Error Behavior in Active Cocaine Users: Poor Awareness of Errors in the Presence of Intact Performance Adjustments

The Role of Executive Control in Human Drug Addiction

Changes in cerebral glucose metabolism during early abstinence from chronic methamphetamine abuse

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