Cerebral glucose uptake in lindane-treated rats

Persistent Organic Pollutant Burden, Experimental POP Exposure, and Tissue Properties Affect Metabolic Profiles of Blubber from Gray Seal Pups

“…NDL-PCBs, DDX, and PBDEs in blubber did not affect glucose uptake, despite evidence of their impacts on glucose homeostasis in other animals. − , Our data suggest that the negative relationship between PBDEs and first year survival of gray seal pups is not driven by direct alterations to adipose metabolic properties. PBDEs may alter adipose function indirectly through endocrine disrupting effects, for example, by altering thyroid or insulin function, ,,, highlighting the need for improved understanding of energy balance regulation in seals, and its disruption by POPs.…”

“…NDL-PCBs, DDX and PBDEs in blubber did not affect glucose uptake, despite evidence of their impacts on glucose homeostasis in other animals [82][83][84][85][86][87]107 . Our data suggest that the negative relationship between PBDEs and first year survival of grey seal pups 104 is not driven by direct alterations to adipose metabolic properties.…”

“…Adipose tissue synthesises triacylglycerol (TAG) from glucose 67,68 , such that glucose uptake rates can be used to investigate metabolic function of adipose tissue. Glucose uptake is altered by POPs at tissue and the whole animal level in other animals [69][70][71][72][73][74][75][76][77][78][79][80][81][82][83][84][85][86][87] . Of glucose taken up by adipose, 20% is stored as TAG, and 70% is used to synthesise lactate 67 .…”

“…Adipose tissue synthesizes triacylglycerol (TAG) from glucose, , such that glucose uptake rates can be used to investigate metabolic function of adipose tissue. Glucose uptake is altered by POPs at tissue and the whole animal level in other animals. − Of glucose taken up by adipose, 20% is stored as TAG, and 70% is used to synthesize lactate . Lactate production is thus an important route of glucose disposal and may be influenced by POP exposure.…”

Persistent Organic Pollutant Burden, Experimental POP Exposure, and Tissue Properties Affect Metabolic Profiles of Blubber from Gray Seal Pups

“…NDL-PCBs, DDX, and PBDEs in blubber did not affect glucose uptake, despite evidence of their impacts on glucose homeostasis in other animals. − , Our data suggest that the negative relationship between PBDEs and first year survival of gray seal pups is not driven by direct alterations to adipose metabolic properties. PBDEs may alter adipose function indirectly through endocrine disrupting effects, for example, by altering thyroid or insulin function, ,,, highlighting the need for improved understanding of energy balance regulation in seals, and its disruption by POPs.…”

“…NDL-PCBs, DDX and PBDEs in blubber did not affect glucose uptake, despite evidence of their impacts on glucose homeostasis in other animals [82][83][84][85][86][87]107 . Our data suggest that the negative relationship between PBDEs and first year survival of grey seal pups 104 is not driven by direct alterations to adipose metabolic properties.…”

“…Adipose tissue synthesises triacylglycerol (TAG) from glucose 67,68 , such that glucose uptake rates can be used to investigate metabolic function of adipose tissue. Glucose uptake is altered by POPs at tissue and the whole animal level in other animals [69][70][71][72][73][74][75][76][77][78][79][80][81][82][83][84][85][86][87] . Of glucose taken up by adipose, 20% is stored as TAG, and 70% is used to synthesise lactate 67 .…”

“…Adipose tissue synthesizes triacylglycerol (TAG) from glucose, , such that glucose uptake rates can be used to investigate metabolic function of adipose tissue. Glucose uptake is altered by POPs at tissue and the whole animal level in other animals. − Of glucose taken up by adipose, 20% is stored as TAG, and 70% is used to synthesize lactate . Lactate production is thus an important route of glucose disposal and may be influenced by POP exposure.…”

Persistent Organic Pollutant Burden, Experimental POP Exposure, and Tissue Properties Affect Metabolic Profiles of Blubber from Gray Seal Pups

“…NDL-PCBs, DDX, and PBDEs in blubber did not affect glucose uptake, despite evidence of their impacts on glucose homeostasis in other animals. − , Our data suggest that the negative relationship between PBDEs and first year survival of gray seal pups is not driven by direct alterations to adipose metabolic properties. PBDEs may alter adipose function indirectly through endocrine disrupting effects, for example, by altering thyroid or insulin function, ,,, highlighting the need for improved understanding of energy balance regulation in seals, and its disruption by POPs.…”

“…NDL-PCBs, DDX and PBDEs in blubber did not affect glucose uptake, despite evidence of their impacts on glucose homeostasis in other animals [82][83][84][85][86][87]107 . Our data suggest that the negative relationship between PBDEs and first year survival of grey seal pups 104 is not driven by direct alterations to adipose metabolic properties.…”

“…Adipose tissue synthesises triacylglycerol (TAG) from glucose 67,68 , such that glucose uptake rates can be used to investigate metabolic function of adipose tissue. Glucose uptake is altered by POPs at tissue and the whole animal level in other animals [69][70][71][72][73][74][75][76][77][78][79][80][81][82][83][84][85][86][87] . Of glucose taken up by adipose, 20% is stored as TAG, and 70% is used to synthesise lactate 67 .…”

“…Adipose tissue synthesizes triacylglycerol (TAG) from glucose, , such that glucose uptake rates can be used to investigate metabolic function of adipose tissue. Glucose uptake is altered by POPs at tissue and the whole animal level in other animals. − Of glucose taken up by adipose, 20% is stored as TAG, and 70% is used to synthesize lactate . Lactate production is thus an important route of glucose disposal and may be influenced by POP exposure.…”

Persistent Organic Pollutant Burden, Experimental POP Exposure, and Tissue Properties Affect Metabolic Profiles of Blubber from Gray Seal Pups

“…NDL-PCBs, DDX, and PBDEs in blubber did not affect glucose uptake, despite evidence of their impacts on glucose homeostasis in other animals. − , Our data suggest that the negative relationship between PBDEs and first year survival of gray seal pups is not driven by direct alterations to adipose metabolic properties. PBDEs may alter adipose function indirectly through endocrine disrupting effects, for example, by altering thyroid or insulin function, ,,, highlighting the need for improved understanding of energy balance regulation in seals, and its disruption by POPs.…”

“…NDL-PCBs, DDX and PBDEs in blubber did not affect glucose uptake, despite evidence of their impacts on glucose homeostasis in other animals [82][83][84][85][86][87]107 . Our data suggest that the negative relationship between PBDEs and first year survival of grey seal pups 104 is not driven by direct alterations to adipose metabolic properties.…”

“…Adipose tissue synthesises triacylglycerol (TAG) from glucose 67,68 , such that glucose uptake rates can be used to investigate metabolic function of adipose tissue. Glucose uptake is altered by POPs at tissue and the whole animal level in other animals [69][70][71][72][73][74][75][76][77][78][79][80][81][82][83][84][85][86][87] . Of glucose taken up by adipose, 20% is stored as TAG, and 70% is used to synthesise lactate 67 .…”

“…Adipose tissue synthesizes triacylglycerol (TAG) from glucose, , such that glucose uptake rates can be used to investigate metabolic function of adipose tissue. Glucose uptake is altered by POPs at tissue and the whole animal level in other animals. − Of glucose taken up by adipose, 20% is stored as TAG, and 70% is used to synthesize lactate . Lactate production is thus an important route of glucose disposal and may be influenced by POP exposure.…”