Cerebral Circulation

Dynamic cerebral autoregulation during step-wise increases in blood pressure during anaesthesia

“…Another way to increase cerebrovascular tone is to increase MAP within the autoregulatory range, as famously demonstrated by Fog in several experiments on animals in the 1930s, 14–17 later confirmed in humans with noninvasive methods 18 . We hypothesised that dynamic CA is dependent on cerebrovascular tone even in the autoregulatory range.…”

“…Nevertheless, neurovascular coupling seems to be preserved during both propofol and volatile anaesthesia, 11,12 although CBF is relatively increased compared to the metabolic rate of oxygen (CMRO 2 ) during volatile anaesthesia. 13 Another way to increase cerebrovascular tone is to increase MAP within the autoregulatory range, as famously demonstrated by Fog in several experiments on animals in the 1930s, [14][15][16][17] later confirmed in humans with noninvasive methods. 18 We hypothesised that dynamic CA is dependent on cerebrovascular tone even in the autoregulatory range.…”

Dynamic cerebral autoregulation during step-wise increases in blood pressure during anaesthesia

“…Another way to increase cerebrovascular tone is to increase MAP within the autoregulatory range, as famously demonstrated by Fog in several experiments on animals in the 1930s, 14–17 later confirmed in humans with noninvasive methods 18 . We hypothesised that dynamic CA is dependent on cerebrovascular tone even in the autoregulatory range.…”

“…Nevertheless, neurovascular coupling seems to be preserved during both propofol and volatile anaesthesia, 11,12 although CBF is relatively increased compared to the metabolic rate of oxygen (CMRO 2 ) during volatile anaesthesia. 13 Another way to increase cerebrovascular tone is to increase MAP within the autoregulatory range, as famously demonstrated by Fog in several experiments on animals in the 1930s, [14][15][16][17] later confirmed in humans with noninvasive methods. 18 We hypothesised that dynamic CA is dependent on cerebrovascular tone even in the autoregulatory range.…”

Cerebral Blood‐Flow Regulation During Hemorrhage

“…This technique requires a craniotomy for direct observation of the precapillary pial vessels on the surface of the brain (63,64,98,135,212), so is generally limited to experimental animal models under both acute and chronic conditions. The responses of the pial vessels are seen as representative of the entire cerebral circulation as they contribute to the majority of cerebrovascular resistance (CVR) (98).…”

Dynamic cerebral autoregulation during step-wise increases in blood pressure during anaesthesia

“…Another way to increase cerebrovascular tone is to increase MAP within the autoregulatory range, as famously demonstrated by Fog in several experiments on animals in the 1930s, 14–17 later confirmed in humans with noninvasive methods 18 . We hypothesised that dynamic CA is dependent on cerebrovascular tone even in the autoregulatory range.…”

“…Nevertheless, neurovascular coupling seems to be preserved during both propofol and volatile anaesthesia, 11,12 although CBF is relatively increased compared to the metabolic rate of oxygen (CMRO 2 ) during volatile anaesthesia. 13 Another way to increase cerebrovascular tone is to increase MAP within the autoregulatory range, as famously demonstrated by Fog in several experiments on animals in the 1930s, [14][15][16][17] later confirmed in humans with noninvasive methods. 18 We hypothesised that dynamic CA is dependent on cerebrovascular tone even in the autoregulatory range.…”

Cerebral Blood‐Flow Regulation During Hemorrhage

“…This technique requires a craniotomy for direct observation of the precapillary pial vessels on the surface of the brain (63,64,98,135,212), so is generally limited to experimental animal models under both acute and chronic conditions. The responses of the pial vessels are seen as representative of the entire cerebral circulation as they contribute to the majority of cerebrovascular resistance (CVR) (98).…”

Dynamic cerebral autoregulation during step-wise increases in blood pressure during anaesthesia

“…Another way to increase cerebrovascular tone is to increase MAP within the autoregulatory range, as famously demonstrated by Fog in several experiments on animals in the 1930s, 14–17 later confirmed in humans with noninvasive methods 18 . We hypothesised that dynamic CA is dependent on cerebrovascular tone even in the autoregulatory range.…”

“…Nevertheless, neurovascular coupling seems to be preserved during both propofol and volatile anaesthesia, 11,12 although CBF is relatively increased compared to the metabolic rate of oxygen (CMRO 2 ) during volatile anaesthesia. 13 Another way to increase cerebrovascular tone is to increase MAP within the autoregulatory range, as famously demonstrated by Fog in several experiments on animals in the 1930s, [14][15][16][17] later confirmed in humans with noninvasive methods. 18 We hypothesised that dynamic CA is dependent on cerebrovascular tone even in the autoregulatory range.…”

Cerebral Blood‐Flow Regulation During Hemorrhage

“…This technique requires a craniotomy for direct observation of the precapillary pial vessels on the surface of the brain (63,64,98,135,212), so is generally limited to experimental animal models under both acute and chronic conditions. The responses of the pial vessels are seen as representative of the entire cerebral circulation as they contribute to the majority of cerebrovascular resistance (CVR) (98).…”