Cerebral Blood Flow Measured With Mri Arterial Spin Labeling (Asl) and Neuroimaging Signs of Age-Related Small Vessel Disease

Objective: to define the role of transcranial electrical stimulation in the assessment of the microvascular bed by contrast-free magnetic resonance (MR) perfusion imaging in patients with chronic cerebral ischemia. Material and methods. Examinations were made in 37 people aged 65-70 years who were diagnosed with chronic cerebral ischemia. The patients were divided into two groups: with and without cognitive impairment (CI). The investigation algorithm involved brain magnetic resonance imaging (MRI) (Toshiba Vantage Titan, 1.5 T), transcranial electrical stimulation (TES) using a TETOS computer hardware diagnostics (Research and Production Firm “BIOSS”) and repeated brain MRI in the arterial spin labelling (ASL) perfusion mode. ASL perfusion data were used to assess cerebral blood flow in the regions of interest before and after TES. Results. Contrast-free MR perfusion imaging revealed relative hyperperfusion within the cortex of the frontal and parietal lobes concurrent with hypoperfusion of the subcortical nuclei and cerebral white matter in patients with CI, which suggests that enhanced cortical blood flow is ineffective and shunting blood flow forms. TES caused a statistically significant change in cerebral perfusion in the non-CI group of patients with chronic cerebral ischemia. After TES by ASL perfusion imaging, the patients without CI showed a diffuse increase in cerebral blood flow (p = 0.002), whereas the group of apparently healthy volunteers exhibited this increase in blood flow. Conclusion. Cerebral perfusion indices before and after TES in patients of all the examined groups define its role as a complementary tool to assess the compensatory capabilities of the microvascular bed by contrast-free MR perfusion imaging in chronic cerebral ischemia.

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Experience with Transcranial Electrical Stimulation in the Assessment of the Microvascular Bed by Contrast-Free Magnetic Resonance Perfusion Imaging in Patients with Chronic Cerebral Ischemia

Chukhontseva

Морозова

Борсуков

2022

Vestn. rentgenol. radiol.

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Neuroimaging patterns of chronic cerebrovascular insufficiency with evaluation of cerebral perfusion depending on the level of cognitive disorders

Chukhontseva

Морозова

Борсуков

2020

Medicinskaâ vizualizaciâ

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Aim. To evaluate the neuroimaging patterns of chronic cerebrovascular insufficiency with cerebral perfusion assessment depending on the level of cognitive impairment.Materials and methods. The 58 patients aged 50–79 years were examined: 45 patients with a diagnosis of сhronic cerebrovascular insufficiency and 13 conditionally healthy volunteers. Patients with Chronic cerebrovascular insufficiency were ranked into three subgroups depending on the severity of cognitive impartment (CI). T1-, T2, T2*- VI, DWI, FLAIR and non-contrast MR perfusion (ASL) were included in the MR-protocol (Toshiba Vantage Titan, 1.5 T). The analysis of MRM patterns of Chronic cerebrovascular insufficiency was carried out according to STRIVE criteria. The total cerebral blood flow and regional in the frontal and parietal lobes were evaluated by the ASLperfusion.Results. A relationship was found between the degree of leukoaraiosis, the type of expansion of the perivascular spaces of Virchow-Robin and the level of CI. According to ASL, total cerebral blood flow is higher in groups without CI and in patients with severe CI. There is a diffuse decrease of cerebral perfusion in patients with mild CI. This phenomenon is explained by initial impairment of the blood-brain barrier permeability, damage to the microvasculature. Relative hyperperfusion in the cortex of the frontal and parietal lobes of patients with dementia indicates the ineffectiveness of increased cortical blood flow and the resulting shunt blood flow due to the high resistance of the altered small cerebral vessels under high pulsating properties of the main arteries.Conclusion. ASL perfusion is a complementary link to the STRIVE criteria in the diagnosis of chronic cerebrovascular insufficiency. The absence of changes in cerebral perfusion in patients with subjective manifestations of chronic cerebrovascular insufficiency makes it advisable to search for new methods for the diagnosis of preclinical stages of vascular cognitive impairment.

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Cerebral Blood Flow Measured With Mri Arterial Spin Labeling (Asl) and Neuroimaging Signs of Age-Related Small Vessel Disease

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Experience with Transcranial Electrical Stimulation in the Assessment of the Microvascular Bed by Contrast-Free Magnetic Resonance Perfusion Imaging in Patients with Chronic Cerebral Ischemia

Experience with Transcranial Electrical Stimulation in the Assessment of the Microvascular Bed by Contrast-Free Magnetic Resonance Perfusion Imaging in Patients with Chronic Cerebral Ischemia

Neuroimaging patterns of chronic cerebrovascular insufficiency with evaluation of cerebral perfusion depending on the level of cognitive disorders

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