Cerebral Aneurysm Associated with an Arachnoid Cyst: 3 Case Reports and a Systematic Review of the Literature

Igarashi, Yutaka; Murai, Yasuo; Shirokane, Kazutaka; Hironaka, Kohei; Sato, Shun; Sugiyama, Makoto; Tachizawa, Takayuki; Morita, Akio

doi:10.1016/j.wneu.2017.09.139

Cited by 6 publications

(2 citation statements)

References 25 publications

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“…Igarashi Y et al . believed that advances in neurosurgical techniques and neuroendoscopy were conducive to fenestration cyst‐peritoneal shunt as a surgical option for treatment of arachnoid cysts (Igarashi et al, ). An intracranial arachnoid cyst is a benign developmental cyst containing cerebrospinal fluid, which is usually found by chance on MRI.…”

Section: Discussionmentioning

confidence: 99%

Association between ELP4 rs986527 polymorphism and the occurrence and development of intracranial arachnoid cyst

Jia

Zhang

et al. 2019

Brain and Behavior

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ObjectiveThe association between ELP4 rs986527 polymorphism and the occurrence and development of intracranial arachnoid cyst was studied in this paper.MethodsEighty‐five patients diagnosed with intracranial arachnoid cysts by cerebral computed tomography scan were selected. Sixty‐three healthy volunteers for medical examination in hospitals served as controls. The cognition, depressive symptoms, and the likelihood of headache, dizziness, head trauma history, dementia, depression, and epilepsy were assessed. ELP4 genotypes and its allele frequency were determined by PCR, endonuclease restriction analysis, and gel electrophoresis.ResultsELP4 rs986527 had three genotypes: TT, TC, and CC. The intracranial arachnoid cyst group showed no statistically significant difference in genotype frequencies compared with healthy controls. There was no significant correlation between ELP4 rs986527 polymorphism and location of intracranial arachnoid cyst. TC and C genotype frequencies were associated with a higher incidence of clinical symptoms than TT genotype frequencies, and C allele frequencies were associated with a significantly higher incidence of clinical symptoms compared with T allele frequencies. There was no significant difference in TNF‐α and IL‐1β levels between TT/TC/CC genotypes before treatment. After treatment, the levels of TNF‐α and IL‐1β were significantly decreased in different genotypes, and the decrease in CC was the greatest. The frequency of TT and TC genotypes was higher than that of CC genotypes.ConclusionELP4 rs986527 polymorphism affected the incidence of clinical symptoms and the levels of TNF‐α and IL‐1β in patients with intracranial arachnoid cysts.

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Section: Discussionmentioning

confidence: 99%

Association between ELP4 rs986527 polymorphism and the occurrence and development of intracranial arachnoid cyst

Jia

Zhang

et al. 2019

Brain and Behavior

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“…Intracranial perianeurysmal cysts are a rare finding in patients with cerebral aneurysms and have been increasingly reported since Marcoux et al first published their findings in 2002 1–12. Perianeurysmal cysts are a different entity from subarachnoid cysts which on occasion can be found surrounding an aneurysm 13–15. Common, but not definitive, features that may allow differentiation of arachnoid cysts from perianeurysmal cysts are timing of development, location, adjacent structural characteristics and cyst contents.…”

Section: Introductionmentioning

confidence: 99%

Intracranial perianeurysmal cysts: case series and review of the literature

Liang

Efendy²,

Winter

et al. 2021

J NeuroIntervent Surg

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BackgroundIntracranial perianeurysmal cysts are a rare finding associated with cerebral aneurysms. Patients may present with symptoms secondary to mass effect from perianeurysmal cysts requiring drainage. These lesions can masquerade as neoplasms if dedicated vascular imaging is not performed, leading to misdiagnosis.MethodA retrospective search of our database was done for intracranial aneurysms that have been treated between 1998 and 2020. A literature search was then performed on PubMed and Google Scholar with the search terms ‘aneurysm’, ‘intracranial/intracerebral’, ‘cyst’, and ‘perianeurysmal cyst’. Patient demographics, aneurysms and cysts characteristics were then summarized as a table and in the discussion.ResultsThree cases where intracranial aneurysm had associated perianeurysmal cysts were found in our database. Combined with the available literature a total of 19 cases of perianeurysmal cysts have thus far been reported since this entity was first described in 2002. A significant number of perianeurysmal cysts (5/19) required intervention. In 5/19 cases the patient presented with a perianeurysmal cyst without a history of subarachnoid hemorrhage. Of the 10 cases where aneurysm follow-up was reported there were 5 cases where there was aneurysm recurrence necessitating re-treatment.ConclusionSignificant variability exists in the patient demographics, aneurysm and cyst characteristics of perianeurysmal cysts. This suggests that there is no single unified etiology and pathogenesis. These lesions are a rare finding and at present do not appear to carry diagnostic or prognostic significance. Management of perianeurysmal cysts is case-dependent and intervention should be considered when treating the related aneurysm, especially in patients with secondary symptoms.

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