Cerebellopontine angle lymphoma presenting as chronic mastoiditis

Nm, Hill; Little, Brad; Vasan, Nilesh; Giles, M

doi:10.1258/0022215001906318

Cited by 6 publications

(5 citation statements)

References 9 publications

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“…And clinical manifestations are related to the anatomical structures surrounding the lesion and volumes of the tumors. PCNSLs of the CPA typically present with trigeminal, facial, audio vestibular and cerebellar dysfunction, including hearing loss, tinnitus, facial palsy, vertigo and ataxia [7,11,18]. Other neurological symptoms include headache, nausea, vomiting, hoarseness and nystagmus [18,15,16].…”

Section: Discussionmentioning

confidence: 99%

Lymphoma of the cerebellopontine angle mimicking metastasis lesion: A case report

Tlemcani¹,

Sahri²,

Hakkou³

et al. 2023

World J. Adv. Res. Rev.

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Primary lymphoma of the cerebellopontine angle (CPA) is rare and uncommon in the central nervous system, accounting for approximately 0.2-2% of all brain tumors. To our knowledge, there have only been 32 cases reported worldwide so far. Here, we report a rare case of B-cell lymphoma in a 56-year-old woman who presented with seizure, dysphagia, and dizziness and showed a lesion involving the left CPA, right frontal horn and septum pellucidum on magnetic resonance imaging (MRI). The primary diagnosis was metastatic tumor; however, Stereotactic biopsy on left CPA lesion was done, and the histological features confirmed the diagnosis of B-cell malignant lymphoma. The patient was treated with chemotherapy, with complete resolution of symptoms after the first chemotherapy session.

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Section: Discussionmentioning

confidence: 99%

Lymphoma of the cerebellopontine angle mimicking metastasis lesion: A case report

Tlemcani¹,

Sahri²,

Hakkou³

et al. 2023

World J. Adv. Res. Rev.

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“…Primary central nervous system lymphoma is a rare and aggressive extranodal non-Hodgkin lymphoma that restricted entirely to the brain, leptomeninges, spinal cord or eyes, without systemic involvement [9,29]. PCNSL accounts for approximately 1-4% of all primary brain tumors [2,24], but its incidence has been increasing over the past 20 years in both immunocompetent and immunocompromised individuals [10,12]. Diffuse large B-Cell Lymphomas are the most common type (~ 90%), while the remaining 10% are poorly characterized by Burkitt's lymphomas, T-Cell lymphomas and low-grade lymphomas [29][30][31][32].…”

Section: Discussionmentioning

confidence: 99%

“…Clinical manifestations of the PCNSLs of the CPA are related to the anatomical structures surrounding the lesion and volumes of the tumors. PCNSLs of the CPA typically present with trigeminal, facial, audiovestibular and cerebellar dysfunction, including hearing loss, tinnitus, facial palsy, vertigo and ataxia [7,10,14,29]. Other neurological symptoms include headache, nausea, vomiting, hoarseness and nystagmus [18,23,24].…”

Section: Discussionmentioning

confidence: 99%

Primary Central Nervous System Lymphoma of the Cerebellopontine Angle: Epidemiological Characteristics and Imaging Features May Be Helpful for Making an Accurate Preoperative Diagnosis

Zheng

Zhang

Huang

et al. 2021

Preprint

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Purpose Primary central nervous system lymphoma (PCNSL) of the cerebellopontine angle (CPA) is rare, thus the preoperative diagnosis is still a challenge.MethodsWe searched the database at our institution and performed a search of English literature in PubMed and Google Scholar. Keywords used were as follows: “primary central nervous system lymphoma”; “cerebellopontine angle”; “lymphoma”. Only cases in the English language that were located in the CPA and contained adequate clinical information pertinent to the analysis were included.Results297 cases of pathologically confirmed PCNSLs were recorded between January 2009 and October 2020 at our institution. 6 cases were located in the CPA, accounting for 2.0% of all PCNSLs. 26 cases meeting the above criteria were found in the literature. Including ours, a total of 32 patients were analyzed. Females were more frequently affected (F/M ratio, 2.2:1). There was a preponderance of left-sided lesions in the PCNSLs of the CPA (L/R ratio, 1.5:1). On CT, 80.0% of them presented as hyperdense lesions. On T1-weighted image, 66.7% appeared isointense. While on T2-weighted image (T2WI), 68.4% appeared isointense/hypointense. After contrast administration, 86.2% presented intense homogeneous enhancement.ConclusionPCNSL of the CPA is extremely rare, accounting for 2.0% of all PCNSLs in our study. There is a preponderance of females and left-sided lesions in this disease. Contrast-enhanced magnetic resonance imaging with T2WI is very helpful in the preoperative diagnosis of the CPA PCNSL. Although rare, lymphoma should be included in the differential diagnosis of CPA lesions.

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“…Primary central nervous system lymphoma is a rare and aggressive extranodal non-Hodgkin lymphoma that restricted entirely to the brain, leptomeninges, spinal cord or eyes, without systemic involvement [28,33]. PCNSL accounts for approximately 1-4% of all primary brain tumors [32,40], but its incidence has been increasing over the past 20 years in both immunocompetent and immunocompromised individuals [14,36]. Diffuse large B-Cell Lymphomas are the most common type (~90%), while the remaining 10% are poorly characterized by Burkitt's lymphomas, T-Cell lymphomas and low-grade lymphomas [5,12,15,33].…”

Section: Discussionmentioning

confidence: 99%

“…Clinical manifestations of the PCNSLs of the CPA are related to the anatomical structures surrounding the lesion and volumes of the tumors. PCNSLs of the CPA typically present with trigeminal, facial, audiovestibular and cerebellar dysfunction, including hearing loss, tinnitus, facial palsy, vertigo and ataxia [14,19,33,38]. Other neurological symptoms include headache, nausea, vomiting, hoarseness and nystagmus [18,31,32].…”

Section: Discussionmentioning

confidence: 99%

Primary Central Nervous System Lymphoma of the Cerebellopontine Angle: Epidemiological Characteristics and Imaging Features may be Helpful for Making an Accurate Preoperative Diagnosis

Zheng

Zhang

Huang

et al. 2021

Preprint

View full text Add to dashboard Cite

Purpose Primary central nervous system lymphoma (PCNSL) of the cerebellopontine angle (CPA) is rare, thus the preoperative diagnosis is still a challenge.Methods We searched the database at our institution and performed a search of English literature in PubMed and Google Scholar. Keywords used were as follows: “primary central nervous system lymphoma”; “cerebellopontine angle”; “lymphoma”. Only cases in the English language that were located in the CPA and contained adequate clinical information pertinent to the analysis were included.Results 297 cases of pathologically confirmed PCNSLs were recorded between January 2009 and October 2020 at our institution. 6 cases were located in the CPA, accounting for 2.0% of all PCNSLs. 26 cases meeting the above criteria were found in the literature. Including ours, a total of 32 patients were analyzed. Females were more frequently affected (F/M ratio, 2.2:1). There was a preponderance of left-sided lesions in the PCNSLs of the CPA (L/R ratio, 1.5:1). On CT, 80.0% of them presented as hyperdense lesions. On T1-weighted image, 66.7% appeared isointense. While on T2-weighted image (T2WI), 68.4% appeared isointense/hypointense. After contrast administration, 86.2% presented intense homogeneous enhancement.Conclusion PCNSL of the CPA is extremely rare, accounting for 2.0% of all PCNSLs in our study. There is a preponderance of females and left-sided lesions in this disease. Contrast-enhanced magnetic resonance imaging with T2WI is very helpful in the preoperative diagnosis of the CPA PCNSL. Although rare, lymphoma should be included in the differential diagnosis of CPA lesions.

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Cerebellopontine angle lymphoma presenting as chronic mastoiditis

Cited by 6 publications

References 9 publications

Lymphoma of the cerebellopontine angle mimicking metastasis lesion: A case report

Lymphoma of the cerebellopontine angle mimicking metastasis lesion: A case report

Primary Central Nervous System Lymphoma of the Cerebellopontine Angle: Epidemiological Characteristics and Imaging Features May Be Helpful for Making an Accurate Preoperative Diagnosis

Primary Central Nervous System Lymphoma of the Cerebellopontine Angle: Epidemiological Characteristics and Imaging Features may be Helpful for Making an Accurate Preoperative Diagnosis

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