Cerebellar pilocytic astrocytoma with leptomeningeal dissemination: Case report

Matsushima, Masashi; Tamaki, Norihiko; Kokunai, Takashi; Nagashima, Tatsuya; Kurata, Hiromitsu; Yamamoto, Kazuki; Imai, Yukihiro; Itoh, Hiroshi

doi:10.1016/s0090-3019(96)00366-7

Cited by 30 publications

(23 citation statements)

References 3 publications

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“…No cases of malignant transformation were verified in our series. Leptomeningeal dissemination and malignant transformation are reported to occur in less than 5% of all benign cerebellar astrocytomas [9, 30, 31, 32, 33, 34]. …”

Section: Discussionmentioning

confidence: 99%

Long-Term Outcome after Resection of Benign Cerebellar Astrocytomas in Children and Young Adults (0–19 Years): Report of 110 Consecutive Cases

Due-Tønnessen¹,

Helseth²,

Scheie³

et al. 2002

Pediatr Neurosurg

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The objective of this retrospective study was to present long-term follow-up data for 110 consecutive children and young adults treated for a benign cerebellar astrocytoma at our institution between 1960 and 2001. Mean age at presentation was 8.9 years. The total surgical mortality was 9%, but declined from 16% in 1960–1977 to 0% in 1988–2001. At the close of the study 97/110 patients were still alive. Nine deaths were surgery related, 2 patients died of shunt-related causes and 2 patients died due to tumor recurrence. Five-, 10- and 25-year survival were 90, 89 and 85%, respectively. Multiple Cox regression analysis showed that tumor infiltration of the brain stem and the time period of surgery were the only explanatory variables significantly associated with survival. Five-year survival improved from 79% in the time period of 1960–1977 to 100% in the time period of 1988–2001. Tumor recurrence after total tumor resection was observed in 5 of 76 (7%) evaluable patients. Growth of residual tumor after subtotal tumor resection was observed in 7 of 26 (27%) evaluable patients. Recent follow- up MR revealed regression of residual tumor in 14 of 16 patients. Only 5 of these patients had received radiotherapy. Thus, spontaneous regression of residual tumor is a more frequent event than growth of residual tumor. The functional outcome was favorable in 82% of the patients [Karnofsky performance index (KPI) ≧90]. Eighteen percent of the patients had moderate to severe disabilities (KPI 50–80). Conclusions: Benign cerebellar astrocytoma is a surgical disease where the prognosis with respect to both survival and functional outcome is favorable. Spontaneous regression of residual tumor is frequently encountered, allowing for observation of residual tumors instead of performing a second resection in cases where a second resection carries a high risk of neurological sequelae.

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Section: Discussionmentioning

confidence: 99%

Long-Term Outcome after Resection of Benign Cerebellar Astrocytomas in Children and Young Adults (0–19 Years): Report of 110 Consecutive Cases

Due-Tønnessen¹,

Helseth²,

Scheie³

et al. 2002

Pediatr Neurosurg

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“…Dissemination of cerebellar PAs can be associated with obstructive hydrocephalus leading to an unfavourable prognosis [32,41,42]. Leptomeningeal dissemination of the cerebellar tumours into the spinal cord might occur many years after primary surgery [45,66,78]; less commonly the meningeal seeding appears at the initial presentation [67]. Spread into the spinal meninges can be observed in PAs of the spinal cord [1,9] and optic chiasm [4,48].…”

Section: Prognosismentioning

confidence: 99%

Heterogeneity of histopathological presentation of pilocytic astrocytoma – diagnostic pitfalls. A review

Matyja

Grajkowska²,

Stępień³

et al. 2016

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“…PAs mainly originate close to the optic chiasm and hypothalamus, in the cerebellum, in the brainstem, and, less commonly, in the cerebral hemispheres and ventricles [4, 5]. Leptomeningeal dissemination (LMD) without malignant transformation of the primary tumor is rare and several case reports in the literature did or did not present LMD initially [1, 2, 4,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21]. The incidence of LMD in patients with PAs is indicated to range from 4% up to 12% [1, 8, 16, 22], which would possibly increase with the widespread use of MRI in cases of PAs to report leptomeningeal metastases.…”

Section: Introductionmentioning

confidence: 99%

Spinal Seeding of a Pilocytic Astrocytoma following Multiple Subtotal Resections

et al. 2005

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Cerebellar pilocytic astrocytoma with leptomeningeal dissemination: Case report

Cited by 30 publications

References 3 publications

Long-Term Outcome after Resection of Benign Cerebellar Astrocytomas in Children and Young Adults (0–19 Years): Report of 110 Consecutive Cases

Long-Term Outcome after Resection of Benign Cerebellar Astrocytomas in Children and Young Adults (0–19 Years): Report of 110 Consecutive Cases

Heterogeneity of histopathological presentation of pilocytic astrocytoma – diagnostic pitfalls. A review

Spinal Seeding of a Pilocytic Astrocytoma following Multiple Subtotal Resections

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