Cerebellar Atrophy in Patients With Long-term Phenytoin Exposure and Epilepsy

Cerebellar volume and long-term use of phenytoin

“…We also found that older patients had CA more frequently, indicating that age or duration of the seizure disorder could also be important in the determination of cerebellar degeneration in these patients 5 . Similar findings have been reported by other studies 2,3,12 , however, data derived from qualitative analyses of CA do not allow more robust statistical correlations and make interpretation of results difficult.…”

Cerebellar volume and long-term use of phenytoin

“…We also found that older patients had CA more frequently, indicating that age or duration of the seizure disorder could also be important in the determination of cerebellar degeneration in these patients 5 . Similar findings have been reported by other studies 2,3,12 , however, data derived from qualitative analyses of CA do not allow more robust statistical correlations and make interpretation of results difficult.…”

Cerebellar atrophy and prognosis after temporal lobe resection.

“…These results differ from those of Ney et al,8 probably due to exclusion criteria (see above) and small sample size in their investigation. The frequency of CPS was not significantly related to cerebellar atrophy in either study.…”

Changes in balance function with chronic antiepileptic drug therapy: A twin and sibling study

“…Studies have suggested a toxic action of certain AEDs such as phenytoin at a cellular level, particularly on the cerebellum and the vestibular nuclear complex . This supports the clinical evidence of cerebellar syndromes including truncal ataxia and cerebellar atrophy in patients taking AED therapy . A previous volumetric magnetic resonance imaging (MRI) study reported that the magnitude of cerebellar atrophy in patients with chronic epilepsy was correlated directly with the duration of the epilepsy, which would be consistent with an effect of chronic AED therapy .…”

Cerebellar volume and long-term use of phenytoin

“…We also found that older patients had CA more frequently, indicating that age or duration of the seizure disorder could also be important in the determination of cerebellar degeneration in these patients 5 . Similar findings have been reported by other studies 2,3,12 , however, data derived from qualitative analyses of CA do not allow more robust statistical correlations and make interpretation of results difficult.…”

Cerebellar atrophy and prognosis after temporal lobe resection.

“…These results differ from those of Ney et al,8 probably due to exclusion criteria (see above) and small sample size in their investigation. The frequency of CPS was not significantly related to cerebellar atrophy in either study.…”

Changes in balance function with chronic antiepileptic drug therapy: A twin and sibling study

“…Studies have suggested a toxic action of certain AEDs such as phenytoin at a cellular level, particularly on the cerebellum and the vestibular nuclear complex . This supports the clinical evidence of cerebellar syndromes including truncal ataxia and cerebellar atrophy in patients taking AED therapy . A previous volumetric magnetic resonance imaging (MRI) study reported that the magnitude of cerebellar atrophy in patients with chronic epilepsy was correlated directly with the duration of the epilepsy, which would be consistent with an effect of chronic AED therapy .…”

Cerebellar volume and long-term use of phenytoin

“…We also found that older patients had CA more frequently, indicating that age or duration of the seizure disorder could also be important in the determination of cerebellar degeneration in these patients 5 . Similar findings have been reported by other studies 2,3,12 , however, data derived from qualitative analyses of CA do not allow more robust statistical correlations and make interpretation of results difficult.…”

Cerebellar atrophy and prognosis after temporal lobe resection.

“…These results differ from those of Ney et al,8 probably due to exclusion criteria (see above) and small sample size in their investigation. The frequency of CPS was not significantly related to cerebellar atrophy in either study.…”

Changes in balance function with chronic antiepileptic drug therapy: A twin and sibling study

“…Studies have suggested a toxic action of certain AEDs such as phenytoin at a cellular level, particularly on the cerebellum and the vestibular nuclear complex . This supports the clinical evidence of cerebellar syndromes including truncal ataxia and cerebellar atrophy in patients taking AED therapy . A previous volumetric magnetic resonance imaging (MRI) study reported that the magnitude of cerebellar atrophy in patients with chronic epilepsy was correlated directly with the duration of the epilepsy, which would be consistent with an effect of chronic AED therapy .…”