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Cited by 293 publications
(229 citation statements)
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“…Although the mechanisms by which ceramide regulates BSX expression are unclear, two sets of observations are relevant: i) ceramide forms gel-phase platforms in the plasma membrane and recruits target proteins for specific signaling that can regulate gene expression [53,54]; and ii) ceramides or their soluble derivatives, such as ceramide-1-phosphate and sphingosine, bind transcription factors and modulate target gene expression [55][56][57][58].…”
Section: Control Of Appetite and Body Weightmentioning
confidence: 99%
“…Although the mechanisms by which ceramide regulates BSX expression are unclear, two sets of observations are relevant: i) ceramide forms gel-phase platforms in the plasma membrane and recruits target proteins for specific signaling that can regulate gene expression [53,54]; and ii) ceramides or their soluble derivatives, such as ceramide-1-phosphate and sphingosine, bind transcription factors and modulate target gene expression [55][56][57][58].…”
Section: Control Of Appetite and Body Weightmentioning
confidence: 99%
“…One product of sphingomyelin hydrolysis by ASM is the lipid ceramide, an important signaling molecule that is elevated in many common diseases (e.g., diabetes, fibrosis, sepsis, etc) [45][46][47]. ASM is a major source of ceramide, both in lysosomes and at the cell membrane.…”
Section: Disease Mechanismmentioning
confidence: 99%
“…Functionally, small rafts coalesce together into domains ranging from 70 nm to 1 µm in diameter, depending on the stimulus and the cell type (Gupta and DeFranco, 2003) through additional specific lipid-lipid or lipid-protein interactions that also modulate their thickness (Castro et al, 2014;Lingwood and Simons, 2010;Silva et al, 2007). In addition, the lipid raft coalescence can be regulated by local accumulation of ceramide generated through the hydrolysis of a major constituent of the microdomains, sphingomyelin, by the acid sphingomyelinase enzyme (ASMase, also known as SMPD1) (Castro et al, 2014). Of note, owing to their rapid trans-bilayer movement (flip-flop), ceramide molecules are distributed between the outer and inner leaflets of the surface membrane.…”
Section: Introductionmentioning
confidence: 99%