Central sensitization induced in thalamic nociceptive neurons by tooth pulp stimulation is dependent on the functional integrity of trigeminal brainstem subnucleus caudalis but not subnucleus oralis

Park, Soo Joung; Sun, Zhenrong; Chiang, Chen Yu; Hu, James W.; Dostrovsky, Jonathan O.; Sessle, Barry J.

doi:10.1016/j.brainres.2006.06.115

Cited by 26 publications

(11 citation statements)

References 52 publications

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“…In these studies we and others have shown that acute or chronic dental pulpitis or trigeminal nerve damage induced functional neuroplasticity reflecting an increased glutamate-mediated excitability (“ central sensitization ”) of nociceptive neurons within the brainstem trigeminal subnucleus caudalis that process orofacial nociceptive afferent inputs (for review see Sessle, 2011), and increased neuronal activity in the trigeminal motor nucleus (Sunakawa et al, 1999; Mostafeezur et al, 2014). Central sensitization following dental manipulations has also been documented in the rodent somatosensory thalamus (Park et al, 2006; Zhang S. et al, 2006; Kaneko et al, 2011). Central sensitization contributes to increased pain sensitivity (allodynia and hyperalgesia) and extraterritorial spread or referral of pain hypersensitivity that characterize many acute and chronic pain conditions (for review, see Sessle, 2011).…”

Section: Discussionmentioning

confidence: 94%

Widespread Volumetric Brain Changes following Tooth Loss in Female Mice

et al. 2017

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Tooth loss is associated with altered sensory, motor, cognitive and emotional functions. These changes vary highly in the population and are accompanied by structural and functional changes in brain regions mediating these functions. It is unclear to what extent this variability in behavior and function is caused by genetic and/or environmental determinants and which brain regions undergo structural plasticity that mediates these changes. Thus, the overall goal of our research program is to identify genetic variants that control structural and functional plasticity following tooth loss. As a step toward this goal, here our aim was to determine whether structural magnetic resonance imaging (sMRI) is sensitive to detect quantifiable volumetric differences in the brains of mice of different genetic background receiving tooth extraction or sham operation. We used 67 adult female mice of 7 strains, comprising the A/J (A) and C57BL/6J (B) strains and a randomly selected sample of 5 of the 23 AXB-BXA strains (AXB1, AXB4, AXB24, BXA14, BXA24) that were produced from the A and B parental mice by recombinations and inbreeding. This panel of 25 inbred strains of genetically diverse inbred strains of mice is used for mapping chromosomal intervals throughout the genome that harbor candidate genes controlling the phenotypic variance of any trait under study. Under general anesthesia, 39 mice received extraction of 3 right maxillary molar teeth and 28 mice received sham operation. On post-extraction day 21, post-mortem whole-brain high-resolution sMRI was used to quantify the volume of 160 brain regions. Compared to sham operation, tooth extraction was associated with a significantly reduced regional and voxel-wise volumes of cortical brain regions involved in processing somatosensory, motor, cognitive and emotional functions, and increased volumes in subcortical sensorimotor and temporal limbic forebrain regions including the amygdala. Additionally, comparison of the 10 BXA14 and 21 BXA24 mice revealed significant volumetric differences between the two strains in several brain regions. These findings highlight the utility of high-resolution sMRI for studying tooth loss-induced structural brain plasticity in mice, and provide a foundation for further phenotyping structural brain changes following tooth loss in the full AXB-BXA panel to facilitate mapping genes that control brain plasticity following orofacial injury.

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Section: Discussionmentioning

confidence: 94%

Widespread Volumetric Brain Changes following Tooth Loss in Female Mice

et al. 2017

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“…Data about the exact location of these regions varies, depending on the sensory modality studied. For example, representations of periodontal mechanosensitive neurons occurred in the most ventral part of the intermediate portion of the VPM (Tabata et al, 2002 ), while oral nociceptive sensations were relayed mostly by the rostral half of the VPM (Park et al, 2006 ; Zhang et al, 2006 ). So the intermediate segment of the VPM differs from the other two VPM segments by relaying sensory pathways of different modalities.…”

Section: Discussionmentioning

confidence: 99%

Lemniscal and extralemniscal compartments in the VPM of the rat

Haidarliu

Rubin

et al. 2008

Front. Neuroanat.

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The ventral posteromedial thalamic nucleus (VPM) of the rat contains at least two major vibrissa-representing compartments: the dorsomedial (VPMdm), which belongs to the lemniscal afferent pathway, and the ventrolateral (VPMvl), which belongs to the extralemniscal afferent pathway. Although input–output projections and functional characteristics that distinguish these two compartments were recently clarified, a comprehensive structural analysis of these compartments and the border between them was lacking. This paper addresses structural and functional relationships between the VPMdm and VPMvl. We found that the size of the VPM is almost constant across individual rats. Next, we computed a canonical map of the VPM in the oblique plane, where structural borders are best visualized. Using the canonical map, and sequential slices cut in oblique and coronal planes, we determined the border between the VPMdm and VPMvl in the standard coronal plane, and verified it with in vivo extracellular recordings. The position of the border between these two vibrissal sub-nuclei changes along the rostrocaudal extent within the VPM due to the relative sizes of these sub-nuclei at any point. The border between the VPMdm and VPMvl, which was revealed by this technique, can now be included in atlases of the rat brain and should facilitate experimental correlation of tactile functions with thalamic regions.

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“…Several research studies have been conducted to examine neuronal sensitization at higher levels along the interoceptive pathway, in particular: (a) spinothalamic tract (Simone et al, 1991 ; Willis, 2002 ); (b) brainstem: rostroventral medulla (Porreca et al, 2002 ); and trigeminal nuclei (Hu et al, 1992 )—especially trigeminal subnucleus caudalis (Cao et al, 2013 ; Wang et al, 2013 ); (c) diencephalum, thalamic neurons (Park et al, 2006 ; Kaneko et al, 2011 ), in the thalamic-anterior cingulate pathway (Shyu and Vogt, 2009 ), hypothalamic neurons (Peng et al, 2011 ; Daviu et al, 2014 ; Donnerer and Liebmann, 2015 ), in the hypothalamic-pituitary-adrenal axis (Daviu et al, 2014 ); (d) telencephalic level, including the anterior cingulate cortex (Wei and Zhuo, 2001 ), amygdala (Neugebauer and Li, 2003 ), and insular cortex (Qiu et al, 2014 ).…”

Section: Central Elaboration: the Sensitization Statementioning

confidence: 99%

Sensitization and Interoception as Key Neurological Concepts in Osteopathy and Other Manual Medicines

2016

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Historically, approaches used in manual medicine to explain patient reported symptoms have been focused on the so-called exteroceptive paradigm. Arguably, this mindset lacks an appropriate "reading system" able to interpret musculoskeletal disorders from a different perspective, where the properties of the nervous system are embraced into a more holistic and functional-related context. Interestingly, if the underpinning mechanisms of a given treatment scenario/effect are taking into account, the majority of research outcomes focuses on a proprioceptive/exteroceptive explanation, leaving ting aside the additional or even central role of interoception. Currently, to date, the application of theoretical knowledge acquired on the relatively recent neuroscientific concepts and evidence concerning of interoception, sensitization, touch, autonomic functions, inflammation, and pain into a clinical/research manual medicine scenario is lacking, even if theoretically, the impact on the possible etiological mechanisms and treatment effects seems to be important. Here, we propose the conceptual foundations for a new way of interpreting and reading patients' clinical reported outcomes scenario based on interoception and sensitization. We argue that this will provide a foundation to create the ground for future research focusing on the hypotheses that manual therapies, specifically osteopathy, can intercede with sensitization states, at all levels, using interoceptive pathways.

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Central sensitization induced in thalamic nociceptive neurons by tooth pulp stimulation is dependent on the functional integrity of trigeminal brainstem subnucleus caudalis but not subnucleus oralis

Cited by 26 publications

References 52 publications

Widespread Volumetric Brain Changes following Tooth Loss in Female Mice

Widespread Volumetric Brain Changes following Tooth Loss in Female Mice

Lemniscal and extralemniscal compartments in the VPM of the rat

Sensitization and Interoception as Key Neurological Concepts in Osteopathy and Other Manual Medicines

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