2017
DOI: 10.18632/aging.101341
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Abstract: Oxidative stress plays a fundamental role in many conditions. Specifically, redox imbalance inhibits endothelial cell (EC) growth, inducing cell death and senescence. We used global transcriptome profiling to investigate the involvement of noncoding-RNAs in these phenotypes. By RNA-sequencing, transcriptome changes were analyzed in human ECs exposed to H2O2, highlighting a pivotal role of p53-signaling. Bioinformatic analysis and validation in p53-silenced ECs, identified several p53-targets among both mRNAs a… Show more

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Cited by 45 publications
(43 citation statements)
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References 83 publications
(124 reference statements)
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“…For example, it has been reported that H 2 O 2 treatment promoted the production of miR-192-5p, and that miR-192-5p-targeted genes were involved in cell cycle, DNA repair and stress response. Accordingly, miR-192-5p overexpression significantly decreased pro- liferation, inducing cell death of endothelial cells [20]. A recent study shows that miR-192-5p targets the mRNA for ATP1B1 (β1 subunit of Na + /K + -ATPase), thereby leading to decreased Na + /K + -ATPase-mediated renal tubular reabsorption and decreased blood pressure [21].…”
Section: Discussionmentioning
confidence: 99%
“…A schematic diagram of EGCG-regulated CTR1 through ERK1/2 and NEAT1 in NSCLC cells. CTR1, copper transporter protein 1; EGCG, (−)-epigallocatechin-3-gallate; ERK, extracellular-regulated kinase; NEAT1, nuclear paraspeckle assembly transcript 1; PCR, polymerase chain reaction; NSCLC, non-small-cell lung cancer; ROS, reactive oxygen species HUVEC, NEAT1 also could be activated by oxidative stress through p53 pathway (Fuschi et al, 2017). In the present study, certain concentrations of EGCG were given to increase the ROS production thereafter induced NEAT1 expression, which means NEAT1 could be regulated by ROS in A549 and H460 cells.…”
Section: Discussionmentioning
confidence: 99%
“…another study showed that neaT1 regulates the mir-107-mediated expression of cyclin-dependent kinase 6 in laryngeal squamous cell cancer (32). a number of studies have demonstrated that the expression of NEAT1 can be activated by NF-κB and p53, and activate PI3K/AKT pathways (33)(34)(35). However, the function of neaT1 in the pathogenesis of glaucoma has not yet been investigated.…”
Section: Discussionmentioning
confidence: 99%
“…When oxidative stress occurs, PI3K/Akt, NF-κB and p53 signaling pathways are directly activated by roS, thus causing damage to ocular structures (7,9). The roS regulate lncrnas, and some lncRNAs influence these pathways (33)(34)(35)(36)(37)(38)(39)(40). a total of 70 differentially expressed lncrnas were obtained, of which 24 participate in the lncrna-mirna-mrna interaction network.…”
Section: Discussionmentioning
confidence: 99%
“…Dysregulation of redox balance affects vascular homeostasis. Hydrogen peroxide treatment significantly increased miR-192 levels, which were prevented by p53 knockdown in endothelial cells [99]. Overexpression of miR-192 inhibited endothelial cell growth.…”
Section: Others: Mir-192 Mir-200 Family and Mir-194mentioning
confidence: 94%