Central Neurocytoma Treatment Modalities: A Systematic Review Assessing the Outcomes of Combined Maximal Safe Resection and Radiotherapy with Gross Total Resection

Mahavadi, Anil; Patel, Priyen M.; Kuchakulla, Manish; Shah, Ashish H.; Eichberg, Daniel G.; Luther, Evan; Komotar, Ricardo J.

doi:10.1016/j.wneu.2020.01.114

Cited by 21 publications

(24 citation statements)

References 47 publications

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“…Mortality reported in 2-cases. The literature advocate that the use of adjuvant radiotherapy in not indicated after gross total resection, however, it can be offered for residual/recurrent tumor, though it remains matter of controversy [ 1 , 8 , 14 , 15 , 18 , 19 ]. In our center we follow the same guidelines.…”

Section: Discussionmentioning

confidence: 99%

“…Central neurocytomas (CNCs) are a rare benign neuroectodermal, intraventricular tumors consisting 0.25–0.5% of primary brain lesions in young adults, commonly found in the supratentorial ventricles. Extra ventricular neurocytoma location is exceptionally rare [ 1 - 3 ]. According to the World Health Organization (WHO) 2016, Categorized as grade II [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Delving Inside the Enigmatic Central Neurocytoma: Electronic Hospital Database Retrieval

et al. 2020

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Introduction: Central neurocytomas (CNCs) appear as a rare benign intraventricular lesions involving <0.5% of primary brain tumors. There are no consensus guidelines for the optimal management strategy, so that this entity still enigmatic. Aim: This review aims to highpoint the entity of central neurocytoma in patients managed by our department and the unique surgical considerations, to review the epidemiology and demographics in patients treated in our institution. Methods: This retrospective analysis was conducted by reviewing tall patients managed at King Hussein Medical Center (KHMC) and their medical records. Patient reports were retrieved from the electronic hospital database for a 14-year period (2004 _ 2018). The review was permitted by the Royal Medical Services Institutional ethics committee. As this study was a retrospective chart review, the requirement for consent was waived. Results: Study revealed 33- patients who had Central neurocytoma as the underlying cause for admission. Of the final population 42.4% of the patients were males. Mean age at diagnosis was 29.48±9.78 years. Two cases were extra-ventricular, to cases were anaplastc. Only one patient developed recurrence. Conclusion: We have one the large series of Central neurocytomas in literature. They are benign and total resection is feasible. New adjuvant therapies are flourishing. Supplementary studies are required clarify the cardinal factors responsible for its pathogenesis; diagnosis; and to consolidate management approaches protocol.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Delving Inside the Enigmatic Central Neurocytoma: Electronic Hospital Database Retrieval

et al. 2020

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“…Hassoun et al [2] proposed the concept of the pathological diagnosis of central neurocytoma for the rst time in 1982, and it was classi ed as grade II by the World Health Organization (WHO) in 2007 and 2016 [3]. Central neurocytomas present as either benign entities or as more aggressive atypical variants, depending on histological atypia and the MIB-1 labeling index, which is a cell proliferation marker [4,5].…”

Section: Introductionmentioning

confidence: 99%

“…However, due to the proximity of intraventricular vasculature and the basal ganglia, achieving total tumor resection is di cult, especially for large central neurocytomas. Additionally, the choice of surgical approach and whether postoperative radiotherapy should be applied are still controversial [5][6][7][8]. In this study, we retrospectively analyzed the treatment outcome of 29 intraventricular central neurocytoma patients.…”

Section: Introductionmentioning

confidence: 99%

Treatment experience of large intraventricular central neurocytoma: a retrospective cohort study

Zhang¹,

Yu²,

Hao³

et al. 2020

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Background: Central neurocytoma is a rare intracranial tumor. Due to the limited number of reported cases, the treatment strategy for central neurocytomas, especially large central neurocytomas, remains controversial. This paper discusses our clinical experience in the treatment of large central neurocytomas.Methods: A retrospective analysis of 29 patients with intraventricular central neurocytomas diagnosed and treated by the same surgeon between April 2012 and September 2019 at the Neurosurgery Departments of Beijing Tiantan Hospital and Hainan General Hospital was performed. The clinical characteristics, treatment plans and prognoses of these patients were reviewed.Results: Among the 29 patients, the average age of onset was 31.93 (17-61) years, and the average maximum tumor diameter was 54.17 ± 15.62 mm. Twenty-three patients (79.3%) had an average maximum diameter greater than 50 mm. Twenty-seven patients (93.1%) underwent transcortical tumor resection. Twenty-seven patients (93.1%) underwent gross total tumor resection. Five patients (17.2%) received radiotherapy after the first operation, and 3 patients (10.3%) had tumor recurrence. None of the patients died.Conclusions: Surgical resection via transcortical fistulotomy is a reliable approach for removal of large central neurocytomas in the ventricle. Patients should be closely observed postoperatively, and MRI of the head should be performed regularly. If a tumor shows progression, then radiotherapy should be considered.

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“…Surgery is the most fundamental treatment [4]. However, the choice of surgical approach, the degree of tumor resection, the prevention and treatment of postoperative brain edema and hydrocephalus, and whether postoperative radiotherapy should be applied are still controversial [5][6][7][8], especially for large tumors occupying bilateral ventricles. Therefore, it is necessary to summarize the clinical treatment experience of these patients.…”

Section: Introductionmentioning

confidence: 99%

Transcortical approach for the treatment of large intraventricular central neurocytoma

Zhang¹,

Yu²,

Hao³

et al. 2020

Preprint

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Background Central neurocytoma is a rare intracranial tumor. Due to the limited number of reported cases in the past, there is still controversy about the treatment strategy for central neurocytoma, especially large central neurocytomas occupying bilateral ventricles. This paper will discuss our clinical experience in the treatment of large central neurocytoma. Methods A retrospective analysis of 29 patients with intraventricular central neurocytoma diagnosed and treated by the same surgeon between April 2012 and September 2019 at the Neurosurgery Departments of Beijing Tiantan Hospital and Hainan General Hospital was performed. The clinical characteristics, treatment plan and prognosis of these patients were discussed. Results Among the 29 patients, the average age of onset was 31.93 (17-61) years, and the average maximum tumor diameter was 54.17 ± 15.62 mm. Among them, 23 patients (79.3%) had an average maximum diameter greater than 5 cm. Twenty-seven patients (93.1%) underwent transcortical tumor resection. Twenty-seven patients (93.1%) achieved gross total tumor resection. Five patients (17.2%) received radiotherapy after the first operation, and 3 patients (10.3%) had tumor recurrence. None of the patients died. Conclusion Operation is the basis of the treatment of central neurocytoma. It is possible for patients to be cured by total resection of the tumor and protection of normal ventricular structure. Transcortical fistulotomy is a reliable approach for the removal of large central neurocytomas in the ventricle. Patients should be closely observed post-operation, and MRI of the head should be rechecked regularly. If tumor progression occurs, then radiotherapy should be considered.

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Central Neurocytoma Treatment Modalities: A Systematic Review Assessing the Outcomes of Combined Maximal Safe Resection and Radiotherapy with Gross Total Resection

Cited by 21 publications

References 47 publications

Delving Inside the Enigmatic Central Neurocytoma: Electronic Hospital Database Retrieval

Delving Inside the Enigmatic Central Neurocytoma: Electronic Hospital Database Retrieval

Treatment experience of large intraventricular central neurocytoma: a retrospective cohort study

Transcortical approach for the treatment of large intraventricular central neurocytoma

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