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Cited by 49 publications
(57 citation statements)
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“…Patients with CNS paracoccidioidomycosis who receive diagnoses and are treated early have a favorable outcome [16]. Although itraconazole has been used successfully to treat neuroparacoccidioidomycosis, the poor penetration of this agent into the CNS may limit its use in such cases [17].…”
Section: Discussionmentioning
confidence: 99%
“…Patients with CNS paracoccidioidomycosis who receive diagnoses and are treated early have a favorable outcome [16]. Although itraconazole has been used successfully to treat neuroparacoccidioidomycosis, the poor penetration of this agent into the CNS may limit its use in such cases [17].…”
Section: Discussionmentioning
confidence: 99%
“…On the other hand, imaging studies with computed tomography (CT) showed a prevalence of NPCM in 12.5% of cases (5 out of 40 asymptomatic patients) and magnetic resonance (MR) in 40% of cases (10 out of 25 patients, 8 of which were asymptomatic). Although these radiological studies involved few patients, they suggest that neurological disease may be more common than routinely thought [6][7][8][9][13][14][15] . The cases in this work all presented multifocal disease and in all cases, it was possible to isolate P. brasiliensis from the affected organs (Table 1).…”
Section: Rev Soc Bras Medmentioning
confidence: 99%
“…Its real prevalence is unknown, though case series report neurological disease in 4.1% to 13.9% of PCM patients [6][7][8][9] . In this study, all NPCM cases that occurred over a 15-year period at a referral center for PCM in Rio de Janeiro, Brazil, were described.…”
mentioning
confidence: 99%
“…Other imaging abnormalities less frequently observed are calcified lesions and diffuse subarachnoid enhancement, the latter seen in less than 10% of cerebral paracoccidioidomycosis cases. 8,9 The most frequent neurologic manifestations are seizures, hemiparesis, cerebellar signs, hydrocephalus, and headache. 10 Meningeal symptoms and signs can be seen in a minority of patients, generally associated with diffuse subarachnoid enhancement and focal brain lesions.…”
mentioning
confidence: 99%