Central nervous system mediators of vasopressin release

Role of putative neurotransmitters in the central gastric antisecretory effect of prostaglandin E2 in rats

“…This is in agreement with the finding that the antisecretory effect of i.c.v.-administered a-adrenoceptor agonists correlates well with their selectivity for a2-adrenoceptors (Nakadate et al, 1982). Furthermore, there is evidence that adrenergic mechanisms participate in the regulation of the release of pituitary vasopressin (Sklar & Schrier, 1983), which, as mentioned earlier, probably mediates the action ofi.c.v.-administered PGE2 on the secretory apparatus. I.c.v.…”

“…Prostaglandins of the E and F series affect a number of the putative central neurotransmitters which have been found to modify gastric secretion (vide supra) and/or the release of vasopressin from the pituitary gland (Sklar & Schrier, 1983). According to Hedqvist (1977), prostaglandins of the E series attenuate noradrenergic neurotransmission in the peripheral autonomic nerves, suggesting that they may have a neuromodulatory role in synaptic transmission.…”

“…According to Roze et al (1980), P-endorphin is a potent inhibitor of gastric acid secretion in rats upon i.c.v. administration, while there is also evidence that opioid mechanisms may participate in the regulation of vasopressin release (Sklar & Schrier, 1983). However, PGE2 may not have any interaction with endogenous opiates in the central nervous system inhibition of gastric secretion since treatment with naloxone was ineffective.…”

Diabetes Insipidus: A Review

“…Prostoglandins also play a role. Centrally, PGE-2 infusion causes increased ADH secretion [19,20]. In the kidneys though, prostaglandin's role is somewhat unclear.…”

Different effects of metoclopramide and domperidone on arginine‐ vasopressin secretion in man.

“…Another possibility is that metoclopramide action is mediated nonspecifically through modulation of other neurotransmitters. In this regard, evidence has accumulated on the role of metoclopramide as a stimulator of muscarinic-cholinergic (Chiodera & Coiro, 1984;Jungman et al, 1984) and serotonergic (Fang & Shian, 1981;Chiodera et al, 1984a;Jungmann et al, 1984) receptors, which are known (particularly the former) to be involved in the mediation of AVP secretion (Sklar & Schrier, 1983).…”