2008
DOI: 10.1001/archneur.65.12.1566
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Abstract: ULTIPLE SCLEROSIS (MS) IS THE MOST common inflammatory disorder of the central nervous system (CNS), leading to progressive neurological deficit. 1 While most diseases of the CNS display some degree of inflammation involving CNSresident innate immune cells (ie, microglia), MS is characterized by the invasion of adaptive immune cells (ie, lymphocytes) into the CNS parenchyma. It is now widely held that MS is an autoimmune disease in which encephalitogenic myelin-reactive T lymphocytes invade the neuropil and in… Show more

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