Central Mechanisms of HPA Axis Regulation by Voluntary Exercise

Stranahan, Alexis M.; Lee, Kim M.; Mattson, Mark P.

doi:10.1007/s12017-008-8027-0

Cited by 175 publications

(165 citation statements)

References 73 publications

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“…Similarly, daily wheel-running distances 180 in rodents generally increase during the initial 14-21 days, before plateauing around distances (Stranahan et al 2008). In line with these observations, rats with a loss-of-208 function mutation in the Melanocortin 4 receptor, which have an attenuated HPA 209 sensitivity (Ryan, et al 2014), demonstrated lower daily running distances, persistent 210 decreases in caloric intake, and dysregulation of the brain-reward related circuitry 211 compared to wild-type controls during VWR (Obici et al 2015).…”

Section: Voluntary Wheel Running Is a Physiological Stressor 155mentioning

confidence: 97%

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Voluntary exercise and depression-like behavior in rodents: are we running in the right direction?

Mul

2018

Journal of Molecular Endocrinology

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Acute or chronic exposure to stress can increase the risk to develop major depressive disorder, a severe, recurrent and common psychiatric condition. Depression places an enormous social and financial burden on modern society. Although many depressed patients are treated with antidepressants, their efficacy is only modest, underscoring the necessity to develop clinically effective pharmaceutical or behavioral treatments. Exercise training produces beneficial effects on stress-related mental disorders, indicative of clinical potential. The pro-resilient and antidepressant effects of exercise training have been documented for several decades. Nonetheless, the underlying molecular mechanisms and the brain circuitries involved remain poorly understood. Preclinical investigations using voluntary wheel running, a frequently used rodent model that mimics aspects of human exercise training, have started to shed light on the molecular adaptations, signaling pathways and brain nuclei underlying the beneficial effects of exercise training on stress-related behavior. In this review, I highlight several neurotransmitter systems that are putative mediators of the beneficial effects of exercise training on mental health, and review recent rodent studies that utilized voluntary wheel running to promote our understanding of exercise training-induced central adaptations. Advancements in our mechanistic understanding of how exercise training induces beneficial neuronal adaptations will provide a framework for the development of new strategies to treat stress-associated mental illnesses.

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Section: Voluntary Wheel Running Is a Physiological Stressor 155mentioning

confidence: 97%

“…2005; Stranahan et al 2008). Thus, as VWR is a threat to homeostasis, it should be 163 considered a physiological stressor, albeit a voluntary and controllable stressor with 164 a distinct temporal profile.…”

Section: Voluntary Wheel Running Is a Physiological Stressor 155mentioning

confidence: 99%

Voluntary exercise and depression-like behavior in rodents: are we running in the right direction?

Mul

2018

Journal of Molecular Endocrinology

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“…The relationship between exercise and HPA activity is complex as it is influenced by duration, type, intensity and chronicity of exercise; characteristics of the stressor used; and characteristics of the population studied (Campeau et al, 2010, Leal-Cerro et al, 2003, Mastorakos et al, 2005, Stranahan et al, 2008. In an animal study, four weeks of swimming exercise was associated with reduced levels of serum corticosterone and depressive behaviours in rats exposed to high levels of glucocorticoids prenatally (Liu et al, 2012a).…”

Section: Exercise and Its Effect On The Hpa Axismentioning

confidence: 99%

A review of lifestyle factors that contribute to important pathways associated with major depression: Diet, sleep and exercise

Lopresti

Hood

Drummond

2013

Journal of Affective Disorders

506

412

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Research on major depression has confirmed that it is caused by an array of biopsychosocial and lifestyle factors. Diet, exercise and sleep are three such influences that play a significant mediating role in the development, progression and treatment of this condition. This review summarises animal and human-based studies on the relationship between these three lifestyle factors and major depressive disorder, and their influence on dysregulated pathways associated with depression, namely neurotransmitter processes, immuno-inflammatory pathways, hypothalamic-pituitary-adrenal (HPA) axis disturbances, oxidative stress and antioxidant defence systems, neuroprogression, and mitochondrial disturbances. Increased attention in future clinical studies on the influence of diet, sleep and exercise on major depressive disorder and investigations of their effect on physiological processes will help to expand our understanding and treatment of major depressive disorder. Mental health interventions, taking into account the bidirectional relationship between these lifestyle factors and major depression are also likely to enhance the efficacy of interventions associated with this disorder.

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“…In support of this notion, Stranahan et al once reported that running-induced elevations in corticosterone levels are prolonged at least in adult male Sprague-Dawley rats. Moreover, there seems to be a positive correlation between basal corticosterone levels and the amount of voluntary wheel running in mice as well as in rats (Stranahan et al 2008). For example, a positive correlation between corticosterone levels and WRA has been reported in house mice (Hsd:ICR strain) selected for high levels of voluntary running over multiple generations.…”

Section: Discussionmentioning

confidence: 98%

“…Despite these beneficial effects of exercise, the precise underlying mechanism is as yet unclear. Some of the recent studies have focused on the hypothalamicpituitary-adrenal (HPA) axis regulation by exercise in rodent species (reviewed in Stranahan et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Adrenal peripheral clock disruption leads to altered circadian behavioral responses to voluntary exercise in middle-aged female mice

Kim

Han

Lee

et al. 2013

Animal Cells and Systems

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(2013) Adrenal peripheral clock disruption leads to altered circadian behavioral responses to voluntary exercise in middle-aged female mice, Animal Cells and Systems, 17:6, 397-405, DOI: 10.1080/19768354.2013 We recently established an adrenal clock-disrupted transgenic mouse line (BMAS) that exhibits a dampened rhythm of corticosterone secretion and reduced amplitude of day/night activity. Here, we observe that voluntary wheel running increases the robustness and amplitude of both body temperature and home cage activity (HCA) rhythms in wild-type, but not in BMAS mice, but without affecting estrous cycle. Surprisingly, wheel running alters the HCA waveform of BMAS females in a way that preferentially increases the late nighttime (ZT21-ZT24) HCA. These results indicate that adrenal clock disruption causes the animals to respond differently to the voluntary exercise cue in middle-aged female mice.

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Central Mechanisms of HPA Axis Regulation by Voluntary Exercise

Cited by 175 publications

References 73 publications

Voluntary exercise and depression-like behavior in rodents: are we running in the right direction?

Voluntary exercise and depression-like behavior in rodents: are we running in the right direction?

A review of lifestyle factors that contribute to important pathways associated with major depression: Diet, sleep and exercise

Adrenal peripheral clock disruption leads to altered circadian behavioral responses to voluntary exercise in middle-aged female mice

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