Central Areolar Choroidal Dystrophy

Analysis of the Morphology and Vascular Layers of the Choroid in Retinitis Pigmentosa Using Spectral-Domain OCT

“…This was an interesting observation in that previous studies using the conventional histological analysis and animal models of RP have demonstrated degeneration of typically the choriocapillaris in regions of atrophy. [1][2][3]6,7 While the present study did not correlate the degree of choroidal thinning with the genetic data and the severity of the disease, evidence has previously shown that these parameters may in fact contribute to choroidal thinning. 15 Such an analysis could not be performed in the present study due to lack of genetic data in most of the RP patients.…”

Analysis of the Morphology and Vascular Layers of the Choroid in Retinitis Pigmentosa Using Spectral-Domain OCT

“…This was an interesting observation in that previous studies using the conventional histological analysis and animal models of RP have demonstrated degeneration of typically the choriocapillaris in regions of atrophy. [1][2][3]6,7 While the present study did not correlate the degree of choroidal thinning with the genetic data and the severity of the disease, evidence has previously shown that these parameters may in fact contribute to choroidal thinning. 15 Such an analysis could not be performed in the present study due to lack of genetic data in most of the RP patients.…”

Multifocal Electroretinograms in Cases of Central Areolar Choroidal Dystrophy

“…This is in accord with the fact that the primary lesion in this disease is in the RPE. [23][24][25] Therefore, our results are consistent with early changes of retinal function in this disease that are presynaptic to the bipolar cells. Local lesions of all retinal area could give similar findings, but it is unlikely in this disease, according to previous reports.…”

“…The marked reduction in the amplitude of K1 in the atrophic area can be explained by the loss of cone cells, RPE, and/or choriocapillaris as has been reported in previous publications. [23][24][25] However, the reduced K1 in areas without visible ophthalmoscopic atrophy cannot be easily explained, although a similar phenomenon was reported in the early stages of CSR 15 and OMD. 16 Both of these diseases also have distinctly localized central retinal lesions, and the K1s outside the central lesion are also abnormal.…”

Choroidal thickness profile in inherited retinal diseases in Indian subjects

“…While the histopathological studies have demonstrated the degeneration of choriocapillaris, loss of photoreceptors, and RPE in the region of atrophy in eyes with various dystrophies,[ 4 5 6 ] we did not find any choroidal thinning in areas of retinal thinning, specifically outer retinal thinning in our study subjects. Due to limited resolution of presently available SD-OCT devices, measurement of choriocapillaris thickness is not possible.…”

Analysis of the Morphology and Vascular Layers of the Choroid in Retinitis Pigmentosa Using Spectral-Domain OCT

“…This was an interesting observation in that previous studies using the conventional histological analysis and animal models of RP have demonstrated degeneration of typically the choriocapillaris in regions of atrophy. [1][2][3]6,7 While the present study did not correlate the degree of choroidal thinning with the genetic data and the severity of the disease, evidence has previously shown that these parameters may in fact contribute to choroidal thinning. 15 Such an analysis could not be performed in the present study due to lack of genetic data in most of the RP patients.…”

Multifocal Electroretinograms in Cases of Central Areolar Choroidal Dystrophy

“…This is in accord with the fact that the primary lesion in this disease is in the RPE. [23][24][25] Therefore, our results are consistent with early changes of retinal function in this disease that are presynaptic to the bipolar cells. Local lesions of all retinal area could give similar findings, but it is unlikely in this disease, according to previous reports.…”

“…The marked reduction in the amplitude of K1 in the atrophic area can be explained by the loss of cone cells, RPE, and/or choriocapillaris as has been reported in previous publications. [23][24][25] However, the reduced K1 in areas without visible ophthalmoscopic atrophy cannot be easily explained, although a similar phenomenon was reported in the early stages of CSR 15 and OMD. 16 Both of these diseases also have distinctly localized central retinal lesions, and the K1s outside the central lesion are also abnormal.…”

Choroidal thickness profile in inherited retinal diseases in Indian subjects

“…While the histopathological studies have demonstrated the degeneration of choriocapillaris, loss of photoreceptors, and RPE in the region of atrophy in eyes with various dystrophies,[ 4 5 6 ] we did not find any choroidal thinning in areas of retinal thinning, specifically outer retinal thinning in our study subjects. Due to limited resolution of presently available SD-OCT devices, measurement of choriocapillaris thickness is not possible.…”

Analysis of the Morphology and Vascular Layers of the Choroid in Retinitis Pigmentosa Using Spectral-Domain OCT

“…This was an interesting observation in that previous studies using the conventional histological analysis and animal models of RP have demonstrated degeneration of typically the choriocapillaris in regions of atrophy. [1][2][3]6,7 While the present study did not correlate the degree of choroidal thinning with the genetic data and the severity of the disease, evidence has previously shown that these parameters may in fact contribute to choroidal thinning. 15 Such an analysis could not be performed in the present study due to lack of genetic data in most of the RP patients.…”

Multifocal Electroretinograms in Cases of Central Areolar Choroidal Dystrophy

“…This is in accord with the fact that the primary lesion in this disease is in the RPE. [23][24][25] Therefore, our results are consistent with early changes of retinal function in this disease that are presynaptic to the bipolar cells. Local lesions of all retinal area could give similar findings, but it is unlikely in this disease, according to previous reports.…”

“…The marked reduction in the amplitude of K1 in the atrophic area can be explained by the loss of cone cells, RPE, and/or choriocapillaris as has been reported in previous publications. [23][24][25] However, the reduced K1 in areas without visible ophthalmoscopic atrophy cannot be easily explained, although a similar phenomenon was reported in the early stages of CSR 15 and OMD. 16 Both of these diseases also have distinctly localized central retinal lesions, and the K1s outside the central lesion are also abnormal.…”

Choroidal thickness profile in inherited retinal diseases in Indian subjects

“…While the histopathological studies have demonstrated the degeneration of choriocapillaris, loss of photoreceptors, and RPE in the region of atrophy in eyes with various dystrophies,[ 4 5 6 ] we did not find any choroidal thinning in areas of retinal thinning, specifically outer retinal thinning in our study subjects. Due to limited resolution of presently available SD-OCT devices, measurement of choriocapillaris thickness is not possible.…”