Cellulose-based injectable hydrogel composite for pH-responsive and controllable drug delivery

Chen, Nusheng; Wang, Hui; Chen, Ling; Vermerris, Wilfred; Wang, Bin; Tong, Zhaohui

doi:10.1016/j.carbpol.2019.115207

Cited by 99 publications

(36 citation statements)

References 59 publications

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“…Injectable hydrogels based on cellulose could encapsulate micelles and perform as a secondary barrier for drug release. [ 143 ] The potential of all‐CNC hydrogels was investigated as injectable drug carrier and sustainable delivery applications. Drug size, solubility, interaction with CNC are determining factors, while the concentration of CNC was found to have a negligible effect on the kinetics of release.…”

Section: Water Interactions In Multiscaled Cellulosic Assembliesmentioning

confidence: 99%

Plant Nanomaterials and Inspiration from Nature: Water Interactions and Hierarchically Structured Hydrogels

et al. 2020

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Recent developments in the area of plant‐based hydrogels are introduced, especially those derived from wood as a widely available, multiscale, and hierarchical source of nanomaterials, as well as other cell wall elements. With water being fundamental in a hydrogel, water interactions, hydration, and swelling, all critically important in designing, processing, and achieving the desired properties of sustainable and functional hydrogels, are highlighted. A plant, by itself, is a form of a hydrogel, at least at given states of development, and for this reason phenomena such as fluid transport, diffusion, capillarity, and ionic effects are examined. These aspects are highly relevant not only to plants, especially lignified tissues, but also to the porous structures produced after removal of water (foams, sponges, cryogels, xerogels, and aerogels). Thus, a useful source of critical and comprehensive information is provided regarding the synthesis of hydrogels from plant materials (and especially wood nanostructures), and about the role of water, not only for processing but for developing hydrogel properties and uses.

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Section: Water Interactions In Multiscaled Cellulosic Assembliesmentioning

confidence: 99%

Plant Nanomaterials and Inspiration from Nature: Water Interactions and Hierarchically Structured Hydrogels

et al. 2020

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“…Since EDC was water-soluble, it can promote the reaction to occur in an aqueous medium. Moreover, the by-products are also water-soluble, so the final product can be easily purified by simple dialysis or gel filtration [ 27 ]. Compared with unmodified CMC, after grafting adipic hydrazide, new spectral peaks were generated at 2.23 ppm (-COCH 2 -), 2.13 ppm (-COCH 2 -) and 1.13 ppm (-CH 2 CH 2 -).…”

Section: Resultsmentioning

confidence: 99%

Inhibitory Effect of pH-Responsive Nanogel Encapsulating Ginsenoside CK against Lung Cancer

Xue

Duan

et al. 2021

Polymers

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Ginsenoside CK is one of the intestinal bacterial metabolites of ginsenoside prototype saponins, such as ginsenoside Rb1, Rb2, Rc, and Rd. Poor water solubility and low bioavailability have limited its application. The nanogel carriers could specifically deliver hydrophobic drugs to cancer cells. Therefore, in this study, a nanogel was constructed by the formation of Schiff base bonds between hydrazide-modified carboxymethyl cellulose (CMC-NH2) and aldehyde-modified β-cyclodextrin (β-CD-CHO). A water-in-oil reverse microemulsion method was utilized to encapsulate ginsenoside CK via the hydrophobic cavity of β-CD. β-CD-CHO with a unique hydrophobic cavity carried out efficient encapsulation of CK, and the drug loading and encapsulation efficiency were 16.4% and 70.9%, respectively. The drug release of CK-loaded nanogels (CK-Ngs) in vitro was investigated in different pH environments, and the results showed that the cumulative release rate at pH 5.8 was 85.5% after 140 h. The methylthiazolyldiphenyl-tetrazolium bromide (MTT) toxicity analysis indicated that the survival rates of A549 cells in CK-Ngs at 96 h was 2.98% compared to that of CK (11.34%). In vivo animal experiments exhibited that the inhibitory rates of CK-Ngs against tumor volume was 73.8%, which was higher than that of CK (66.1%). Collectively, the pH-responsive nanogel prepared herein could be considered as a potential nanocarrier for CK to improve its antitumor effects against lung cancer.

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“…Under low pH conditions, the micelle and network were disassembled, inducing the drug delivery. [ 264 ] Wound healing is a natural characteristic of skins to fix damaged tissues, and this phenomenon contains four important processes (i.e., coagulation, inflammatory, cell proliferation, and collagen fiber regeneration. [ 265 ] Polysaccharide‐based hydrogels have the potential to provide an appropriate pH environment, humidity, oxygen pressure, and prevent microbial invasion.…”

Section: Applications Of Polysaccharide‐based Hydrogelsmentioning

confidence: 99%

Recent advances in polysaccharide‐based hydrogels for synthesis and applications

Lin

2021

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Hydrogels are three‐dimensional (3D) crosslinked hydrophilic polymer networks that have garnered tremendous interests in many fields, including water treatment, energy storage, and regenerative medicine. However, conventional synthetic polymer hydrogels have poor biocompatibility. In this context, polysaccharides, a class of renewable natural materials with biocompatible and biodegradable properties, have been utilized as building blocks to yield polysaccharide‐based hydrogels through physical and/or chemical crosslinking of polysaccharides via a variety of monomers or ions. These polysaccharide‐derived hydrogels exhibit peculiar physicochemical properties and excellent mechanical properties due to their unique structures and abundant functional groups. This review focuses on recent advances in synthesis and applications of polysaccharide‐based hydrogels by capitalizing on a set of biocompatible and biodegradable polysaccharides (i.e., cellulose, alginate, chitosan, and cyclodextrins [CDs]). First, we introduce the design and synthesis principles for crafting polysaccharide‐based hydrogels. Second, polysaccharide‐based hydrogels that are interconnected via various crosslinking strategies (e.g., physical crosslinking, chemical crosslinking, and double networking) are summarized. In particular, the introduction of noncovalent and/or dynamic covalent interactions imparts polysaccharide‐based hydrogels with a myriad of intriguing performances (e.g., stimuli–response and self‐recovery). Third, the diverse applications of polysaccharide‐based hydrogels in self‐healing, sensory, supercapacitor, battery, drug delivery, wound healing, tissues engineering, and bioimaging fields are discussed. Finally, the perspectives of polysaccharide‐based hydrogels that promote their future design to enable new functions and applications are outlined.

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Cellulose-based injectable hydrogel composite for pH-responsive and controllable drug delivery

Cited by 99 publications

References 59 publications

Plant Nanomaterials and Inspiration from Nature: Water Interactions and Hierarchically Structured Hydrogels

Plant Nanomaterials and Inspiration from Nature: Water Interactions and Hierarchically Structured Hydrogels

Inhibitory Effect of pH-Responsive Nanogel Encapsulating Ginsenoside CK against Lung Cancer

Recent advances in polysaccharide‐based hydrogels for synthesis and applications

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