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“…For example, hypocalcemia negatively influence the permeability of membranes and the power of smooth muscle contractions, which can impact blood pressure and could initiate preterm uterine contractions [8]. Furthermore, aging process involves cellular senescence in body tissues and organs ultimately leading to the production of reactive oxygen species (ROS) which impairs proper function of cells [9,10]. Therefore, adequate daily intake is crucial.…”
Section: Introductionmentioning
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“…For example, hypocalcemia negatively influence the permeability of membranes and the power of smooth muscle contractions, which can impact blood pressure and could initiate preterm uterine contractions [8]. Furthermore, aging process involves cellular senescence in body tissues and organs ultimately leading to the production of reactive oxygen species (ROS) which impairs proper function of cells [9,10]. Therefore, adequate daily intake is crucial.…”
Section: Introductionmentioning
“…Paradoxically, this has created a new clinical challenge, i.e. a vast array of chronic degenerative diseases, including heart disease, cancer, diabetes, neurodegeneration, often accompanied by the development of debilitating conditions, such as sarcopenia and osteoporosis (Franceschi et al, 2018;Khosla, Farr, & Kirkland, 2018;Rodier, Zhou, & Ferbeyre, 2018). To combat these pathologies of aging, there has been growing interest in geroscience, a research field focused on identifying/targeting common biological mechanisms that drive aging and underlie aging-related pathologies (Franceschi et al, 2018;Seals, Justice, & LaRocca, 2016).…”
Section: Introductionmentioning
“…To combat these pathologies of aging, there has been growing interest in geroscience, a research field focused on identifying/targeting common biological mechanisms that drive aging and underlie aging-related pathologies (Franceschi et al, 2018;Seals, Justice, & LaRocca, 2016). Recent advancements in this field have identified several common key risk factors, such as chronic-low grade inflammation, cellular senescence, metabolic dysfunction, macromolecular damage, genomic instability, reduced responsiveness to stress and altered proteostasis, associated with numerous of these 'comorbidities of aging' (Gerakis & Hetz, 2018;Howcroft et al, 2013;Khosla et al, 2018;Rodier et al, 2018;Seals et al, 2016).…”
Section: Introductionmentioning