1966
DOI: 10.1093/jn/89.3.300
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Cellular Response in Rats during Malnutrition at Various Ages

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Cited by 925 publications
(303 citation statements)
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“…It is well-known that starvation and malnutrition are accompanied by atrophy of lymphoid organs and tissues, among which thymus involution is most prominent (Melampy et al, 1950;Schwartz et al, 1951;Winick and Noble, 1966;Kato et al, 1978). In the present experiments, lymphocyte destruction began to occur in the thymic cortex on a large scale shortly after the beginning of starvation, so that the boundary between the cortex and medulla became indistinct within 3 or 4 days.…”
Section: Resultssupporting
confidence: 49%
“…It is well-known that starvation and malnutrition are accompanied by atrophy of lymphoid organs and tissues, among which thymus involution is most prominent (Melampy et al, 1950;Schwartz et al, 1951;Winick and Noble, 1966;Kato et al, 1978). In the present experiments, lymphocyte destruction began to occur in the thymic cortex on a large scale shortly after the beginning of starvation, so that the boundary between the cortex and medulla became indistinct within 3 or 4 days.…”
Section: Resultssupporting
confidence: 49%
“…A congenital deficiency in uterine blood supply produced similar effects (25). In many instances, such long-term effects are associated with undemutrition early in pregnancy, because of the increased sensitivity of the cell to undemutrition during periods of cell division compared with periods of cell growth (26,27). In this context, it is of interest to note that the twofold increase in the risk of schizophrenia and schizoid personality disorder among males and females who were prenataliy exposed to the Dutch famine is associated with intrauterine exposure in early pregnancy and not in late pregnancy (28,29).…”
Section: Discussionmentioning
confidence: 99%
“…I t was notice d tha t th e animal s unde r protei n deprivation durin g prenata l an d lactatio n period s presente d greate r quantit y o f larg e an d strongl y basophili c myenteric neurons. This suggest s that neurons have accumulated protei n i n the cytoplasm .KEY WORDS: enteric neurons, myenteric plexus, proteic deprivation, proximal colon, gestation, lactation.Reviewing the available data, it was found that many authors direct their studies to the effec t of undernutrition o n the central nervous system 3,16,18,19 . Fe w were the studies foun d relatin g t o the effects of undernutrition on the peripheral nervous system, and fewer were the studies found concerning …”
mentioning
confidence: 99%
“…Reviewing the available data, it was found that many authors direct their studies to the effec t of undernutrition o n the central nervous system 3,16,18,19 . Fe w were the studies foun d relatin g t o the effects of undernutrition on the peripheral nervous system, and fewer were the studies found concerning …”
mentioning
confidence: 99%