Cell Reports volume 3, issue 2, P282-290 2013 DOI: 10.1016/j.celrep.2013.01.020 View full text
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Owen Randlett, Ryan B. MacDonald, Takeshi Yoshimatsu, Alexandra D. Almeida, Sachihiro C. Suzuki, Rachel O. Wong, William A. Harris

Abstract: SummaryHow synaptic neuropil is formed within the CNS is poorly understood. The retinal inner plexiform layer (IPL) is positioned between the cell bodies of amacrine cells (ACs) and retinal ganglion cells (RGCs). It consists of bipolar cell (BC) axon terminals that synapse on the dendrites of ACs and RGCs intermingled with projections from Müller glia (MG). We examined whether any of these cellular processes are specifically required for the formation of the IPL. Using genetic and pharmacological strategies, w…

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