Cellular localisation of a water-soluble fullerene derivative

C60 affects DNA replication in vitro by decreasing the melting temperature of DNA templates

“…The modified C 60 could deliver DNA plasmid into cell by endocytosis, and the derivates of C 60 could inhibit human immunodeficiency virus (HIV) reverse transcriptase or moloney murine leukemia virus (MMLV) reverse transcriptase activity [3,12,27,28]. Although the actual biological targets of these approaches are not clear, it was suggested to be related with DNA or enzymes.…”

Photodynamic therapy with fullerenes

“…In serum-free medium they found a time (up to 6 h) and concentration dependent uptake so that 50% of added fullerene was taken up. Foley et al 71 used indirect immunofluorescence staining with antibodies that recognize fullerenes and other organelle probes to show that a dicarboxylic acid derivative localized in mitochondria and other intracellular membranes. A recent report5 has in fact used a pristine C 60 preparation obtained by sonication in methanol (different from the more commonly used toluene) and giving uniformly sized particles with a mean size of 32.7 nm together, with photoluminescence detection at 750 nm after excitation at 488 -nm, to demonstrate cell uptake in normal and malignant breast cells after culturing them on fullerene coated dishes.…”

Structural Features of Highly Stable Reproducible C60Fullerene Aqueous Colloid Solution Probed by Various Techniques

“…D ue to its nanom eter size, the pristine C60 fullerenes are able to interact w ith biom ole cules (3,4) an d penetrate th ro u g h the cell m em brane (5,6). They exhibit antioxidant properties (7) and, being non-toxic (at low concentration at least) (8)(9)(10)(11)(12)(13), exert specific health effects (e.g., suppress the grow th o f m alignant tum ors (14,15)).…”