2016
DOI: 10.1039/c6mb00388e
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Abstract: A single cell creates surprising heterogeneity in a multicellular organism. While every organismal cell shares almost an identical genome, molecular interactions in cells alter the use of DNA sequences to modulate the gene of interest for specialization of cellular functions. Each cell gains a unique identity through molecular coding across the DNA, RNA, and protein conversions. On the other hand, loss of cellular identity leads to critical diseases such as cancer. Most cell identity dissection studies are bas… Show more

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Cited by 18 publications
(13 citation statements)
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“…The concept of cellular heterogeneity was first proposed in 1957 (3). Single cells are considered the smallest structural and functional unit of an organism, as each cell represents a unique unit with molecular coding across the DNA, RNA, and protein conversions (4). Thus, relevant studies, especially the omics studies, are expected to be carried out at the single cell level.…”
Section: Introductionmentioning
confidence: 99%
“…The concept of cellular heterogeneity was first proposed in 1957 (3). Single cells are considered the smallest structural and functional unit of an organism, as each cell represents a unique unit with molecular coding across the DNA, RNA, and protein conversions (4). Thus, relevant studies, especially the omics studies, are expected to be carried out at the single cell level.…”
Section: Introductionmentioning
confidence: 99%
“…Advances in measurement technologies now allow to obtain gene expression levels at the single cell level. It offers a much more accurate view than population-based measurements, that has been obscured by mean population-based averaging [1], [2]. It has among other established that there is a high cell-to-cell variability in gene expression, and that this variability has to be taken into account when examining a differentiation process at the single-cell level [3], [4], [5], [6], [7], [8], [9], [10], [11].…”
Section: Introductionmentioning
confidence: 99%
“…It can be influenced by several factors that can change their cellular behaviors such as proliferation, differentiation, and metabolic activities (Yin et al 2019). Due to the change in their cellular responses, a wide heterogeneity occurred in between the single-cell even in the same organism (Bateman and Conrads 2018;Coskun et al 2016;Gutierrez et al 2017;Macaulay and Voet 2014;Paulsson 2013;Zhang and Vertes 2018). It has been noted that the concentration and compositions of the chemical substances are also different from two homologous cells of the same individual (Cao and Wu 2017;Evans and Ling 2017;Ren et al 2013).…”
Section: Introductionmentioning
confidence: 99%