volume 28, issue 12, P1419-1427 1995
DOI: 10.1016/0021-9290(95)00090-9
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Clark M. Stanford, Jeff W. Stevens, Richard A. Brand

Abstract: Osteoblastic cells respond to mechanical stimuli with alterations in proliferation and/or phenotypic expression. In some cases, these responses occur within only a few applications of stimuli (i.e. 'cycle-dependent trigger response') rather than in a dose-dependent manner. To explore potential mechanisms of the cycle dependent trigger response, we raised the following questions: (1) Does strain of bone cells alter gene expression; if so, how quickly does it occur and how long does it last? (2) Are alterations …

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