Cellular and Molecular Cascades during Liver Regeneration

Sadri, Ali-Reza; Jeschke, Marc G.; Amini-Nik, Saeid

doi:10.17140/sroj-2-110

Cited by 6 publications

(5 citation statements)

References 58 publications

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“…The angiogenic phase in which the nonparenchymal cells such as HSCs, KCs and hepatic endothelial cells undergo proliferation in response to signals derived from proliferating hepatocytes. It occurs immediately after the inductive period and continues for 2–3 days (Michalopoulos, 2007; Sadri et al, 2015). …”

Section: Developmental Pathways Of Liver Regenerationmentioning

confidence: 99%

Section: Developmental Pathways Of Liver Regenerationmentioning

confidence: 99%

“…Notably, the regenerative response of hepatocytes precedes and triggers the expansion of cholangiocytes. This step commences at the end of the priming phase and lasts for 72 hrs reaching the peak at 24–36 hrs after PH (Michalopoulos, ; Sadri, Jeschke, & Amini‐Nik, ). The angiogenic phase in which the nonparenchymal cells such as HSCs, KCs and hepatic endothelial cells undergo proliferation in response to signals derived from proliferating hepatocytes. It occurs immediately after the inductive period and continues for 2–3 days (Michalopoulos, ; Sadri et al, ).…”

Section: Developmental Pathways Of Liver Regenerationmentioning

confidence: 99%

“…Liver sinusoidal endothelial cells (LSECs) respond to hepatocyte‐released growth factors by getting replicated and producing more HGFs which, in turn, stimulate the hepatocytes. During the angiogenic phase of hepatic proliferation, a physiological event called angiogenesis commences at 2–3 days and terminates at 5–6 days after PH (Michalopoulos, ; Michalopoulos & DeFrances, ; Sadri et al, ). It is characterized by the development of new blood vessels from preexisting ones.…”

Section: Developmental Pathways Of Liver Regenerationmentioning

confidence: 99%

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Understanding the marvels behind liver regeneration

Rmilah

Zhou

Nelson

et al. 2019

WIREs Developmental Biology

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Tissue regeneration is a process by which the remaining cells of an injured organ regrow to offset the missed cells. This field is relatively a new discipline that has been a focus of intense research by clinicians, surgeons, and scientists for decades. It constitutes the cornerstone of tissue engineering, creation of artificial organs, and generation and utilization of therapeutic stem cells to undergo transformation to different types of mature cells. Many medical experts, scientists, biologists, and bioengineers have dedicated their efforts to deeply comprehend the process of liver regeneration, striving for harnessing it to invent new therapies for liver failure. Liver regeneration after partial hepatectomy in rodents has been extensively studied by researchers for many years. It is divided into three important distinctive phases including (a) Initiation or priming phase which includes an overexpression of specific genes to prepare the liver cells for replication, (b) Proliferation phase in which the liver cells undergo a series of cycles of cell division and expansion and finally, (c) termination phase which acts as brake to stop the regenerative process and prevent the liver tissue overgrowth. These events are well controlled by cytokines, growth factors, and signaling pathways. In this review, we describe the function, embryology, and anatomy of human liver, discuss the molecular basis of liver regeneration, elucidate the hepatocyte and cholangiocyte lineages mediating this process, explain the role of hepatic progenitor cells and elaborate the developmental signaling pathways and regulatory molecules required to procure a complete restoration of hepatic lobule. This article is categorized under: Adult Stem Cells, Tissue Renewal, and Regeneration > Regeneration Signaling Pathways > Global Signaling Mechanisms, Gene Expression and Transcriptional Hierarchies > Cellular Differentiation

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Section: Developmental Pathways Of Liver Regenerationmentioning

confidence: 99%

Section: Developmental Pathways Of Liver Regenerationmentioning

confidence: 99%

Section: Developmental Pathways Of Liver Regenerationmentioning

confidence: 99%

Section: Developmental Pathways Of Liver Regenerationmentioning

confidence: 99%

See 2 more Smart Citations

Understanding the marvels behind liver regeneration

Rmilah

Zhou

Nelson

et al. 2019

WIREs Developmental Biology

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show abstract

“…During the regenerative process, the liver goes through three distinctive phases: (a) initiation or priming phase, (b) proliferation phase, and (c) termination phase. These phases occur in chronological order, regulated by manifold ligands and signaling pathways [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of Gut Recolonization on Liver Regeneration: Hepatic Matrisome Gene Expression after Partial Hepatectomy in Mice

Amin,

Hairulhisyam,

Aqilah

et al. 2023

IJMS

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The hepatic matrisome is involved in the remodeling phase of liver regeneration. As the gut microbiota has been implicated in liver regeneration, we investigated its role in liver regeneration focusing on gene expression of the hepatic matrisome after partial hepatectomy (PHx) in germ-free (GF) mice, and in GF mice reconstituted with normal gut microbiota (XGF). Liver mass restoration, hepatocyte proliferation, and immune response were assessed following 70% PHx. Hepatic matrisome and collagen gene expression were also analyzed. Reduced liver weight/body weight ratio, mitotic count, and hepatocyte proliferative index at 72 h post PHx in GF mice were preceded by reduced expression of cytokine receptor genes Tnfrsf1a and Il6ra, and Hgf gene at 3 h post PHx. In XGF mice, these indices were significantly higher than in GF mice, and similar to that of control mice, indicating normal liver regeneration. Differentially expressed genes (DEGs) of the matrisome were lower in GF compared to XGF mice at both 3 h and 72 h post PHx. GF mice also demonstrated lower collagen expression, with significantly lower expression of Col1a1, Col1a2, Col5a1, and Col6a2 compared to WT mice at 72 h post PHx. In conclusion, enhanced liver regeneration and matrisome expression in XGF mice suggests that interaction of the gut microbiota and matrisome may play a significant role in the regulation of hepatic remodeling during the regenerative process.

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Liver Regeneration in Acute and Acute-on-Chronic Liver Failure

Leventhal

Steer

2020

Liver Failure

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Cellular and Molecular Cascades during Liver Regeneration

Cited by 6 publications

References 58 publications

Understanding the marvels behind liver regeneration

Understanding the marvels behind liver regeneration

Impact of Gut Recolonization on Liver Regeneration: Hepatic Matrisome Gene Expression after Partial Hepatectomy in Mice

Liver Regeneration in Acute and Acute-on-Chronic Liver Failure

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