2017
DOI: 10.1111/acel.12702
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Abstract: SummaryAccelerated cellular aging and reduced lifespan have recently been shown in birds chronically infected with malaria parasites. Whether malaria infection also affects cellular aging in humans has not been reported. Here, we assessed the effect of a single acute Plasmodium falciparum malaria infection on cellular aging dynamics in travelers prospectively followed over one year in Sweden. DNA and RNA were extracted from venous blood collected at the time of admission and repeatedly up to one year. Telomere… Show more

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Cited by 35 publications
(46 citation statements)
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“…As the standard curves are expressed in ng/μl (the unit used to calculate T/S ratio), hence, this approach can be compared with ΔΔC T values as −log 2 of T/S is equal to ΔΔC T . The T/S ratio is referred here as “telomere length.” This method showed a very high within and in‐between plate repeatability of telomere length quantification (Asghar et al, ; Asghar et al, ; methodological details are presented in Data S1).…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…As the standard curves are expressed in ng/μl (the unit used to calculate T/S ratio), hence, this approach can be compared with ΔΔC T values as −log 2 of T/S is equal to ΔΔC T . The T/S ratio is referred here as “telomere length.” This method showed a very high within and in‐between plate repeatability of telomere length quantification (Asghar et al, ; Asghar et al, ; methodological details are presented in Data S1).…”
Section: Methodsmentioning
confidence: 99%
“…This method showed a very high within and in-between plate repeatability of telomere length quantification (Asghar et al, 2015;Asghar et al, 2017; methodological details are presented in Data S1).…”
Section: Telomere Length Quantificationmentioning
confidence: 99%
“…Studies in humans have repeatedly shown that patients with chronic infections have shorter telomeres in immune cells than healthy individuals, and that individuals with shorter telomeres have increased mortality rates [11]. This literature in humans has established a relationship between health status and the rate of ageing, but the causal role of immune activation on telomere shortening and human longevity remains elusive owing to obvious experimental limitations with human subjects [12]. A handful of experimental studies in animal model species have demonstrated that exposure to pathogens results in accelerated telomere erosion in immune cells.…”
Section: What Do We Know?mentioning
confidence: 99%
“…The measurements of TL in blood leukocytes are always reflections of the cell pool used at that specific time, where leukocytes have high turnover rates, which could also be influenced by infections and chronic diseases. 3 Nevertheless, TL from different tissues (leukocyte, skin, fat, muscle) are correlated within the same individual 4 although these tissues have different proliferative capacities, and hence the telomere attrition rate over the life course may look different.…”
Section: Article See P 616mentioning
confidence: 99%