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Cited by 312 publications
(218 citation statements)
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References 62 publications
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“…These findings are consistent with studies demonstrating that the endothelial cell cytoskeleton undergoes dramatic structural rearrangement during the transition between a quiescent and proliferative state (33)(34)(35). However, other than one report in which actin was demonstrated on the surface of cultured endothelial cells (36), there has been little evidence for exposure of cytoskeletal components on the endothelial surface.…”
Section: Discussionsupporting
confidence: 88%
See 1 more Smart Citation
“…These findings are consistent with studies demonstrating that the endothelial cell cytoskeleton undergoes dramatic structural rearrangement during the transition between a quiescent and proliferative state (33)(34)(35). However, other than one report in which actin was demonstrated on the surface of cultured endothelial cells (36), there has been little evidence for exposure of cytoskeletal components on the endothelial surface.…”
Section: Discussionsupporting
confidence: 88%
“…The studies reported here suggest that HKa may affect the endothelial cell cytoskeleton directly, perhaps causing secondary alterations in downstream signaling pathways dependent on reciprocal interactions between the cytoskeleton and adhesion receptors. Indeed, biomechanical influences mediated through the cytoskeleton play a critical role in processes such as cell-cycle entry, cellular growth, and apoptosis (33)(34)(35). Although both TM-311 and HK also bind to tropomyosin, neither induces endothelial apoptosis, suggesting that HKa binds to TM in a unique manner and induces ligand specific responses.…”
Section: Discussionmentioning
confidence: 99%
“…The cellular cytoskeleton plays a critically important role in the angiogenic process (2). The cytoskeleton undergoes dramatic structural rearrangements during the various stages of angiogenesis, including proliferation, migration, and differentiation of endothelial cells into vascular structures (2).…”
Section: Introductionmentioning
confidence: 99%
“…The cytoskeleton undergoes dramatic structural rearrangements during the various stages of angiogenesis, including proliferation, migration, and differentiation of endothelial cells into vascular structures (2). Although the actin cytoskeleton is known to play a pivotal role in the regulation of changes in endothelial cell shape and endothelial cell migration, there is mounting recent evidence in support of the involvement of the microtubule cytoskeleton in angiogenesis (2,3). Microtubules are essential for cell signaling, protein and organelle trafficking, cell migration, and many other cellular functions.…”
Section: Introductionmentioning
confidence: 99%
“…We currently have little understanding of how dynamic and integrated changes in cell form take place or how transmission of mechanical stresses between cells and ECM alters cell and nuclear structure, even though these events clearly play a critical role in growth and differentiation (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(31)(32). Our results show that cell surface integrin receptors transmit tensile stresses that mechanically distort interconnected CSK and nucleoskeletal networks and thereby drive changes in cell and nuclear form in time periods much faster than those required for polymerization.…”
mentioning
confidence: 99%