Cell Proliferation, Differentiation and Transformation in the Rat Submandibular Gland during Early Postnatal Growth. A Quantitative and Morphological Study

Alvares, Eliana Parisi; Sesso, Antônio

doi:10.1679/aohc1950.38.177

Cited by 60 publications

(50 citation statements)

References 38 publications

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“…This fact agrees with the data of ALVARES and SESSO (1975) in the immature submandibular gland and support the hypothesis of an epithelial origin for this cellular category (TAMARIN, 1966;HANKS and CHAUDHRY, 1971). The results of this report show also a maturational parallelism among the evolution of the myoepithelial and the acinar cells.…”

Section: Myoepithelial Cellssupporting

confidence: 92%

“…The data of CHANG (1674) and ALVARES and SESSO (1975) indicate that the intercalated duct cells of the submandibular gland at early postpartum, migrate towards the striated duct. During this process they should undergo morphological differentiation.…”

Section: Myoepithelial Cellsmentioning

confidence: 99%

“…On the other hand CHANG (1974) and ALVARES and SESSO (1975) obtained indirect evidence that in the developing submandibular gland of the rat the cells of the intercalated duct migrate towards the striated duct. Similar movements of cells seem to occur in the parotid and sublingual glands from suckling rats (TAGA, 1976).…”

mentioning

confidence: 99%

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Ultrastructural Studies on Developing Parotid Gland of the Rat at Early Postnatal Periods

Taga

Sesso

1979

Arch. Histol. Jap., Arch. Histol. Jpn

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Section: Myoepithelial Cellssupporting

confidence: 92%

Section: Myoepithelial Cellsmentioning

confidence: 99%

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Ultrastructural Studies on Developing Parotid Gland of the Rat at Early Postnatal Periods

Taga

Sesso

1979

Arch. Histol. Jap., Arch. Histol. Jpn

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“…However, there are other equally viable alternatives. These are based in part on the fact that well-differentiated cells undergoing mitosis are common in salivary glands in adults (Leblond, 1964;Redman and Sreebny, 1970b;Chang, 1974;Alvares and Sesso, 1975;Hand and Ho, 1985;Schwartz-Arad et al, 1988) and in several experimental models of regeneration after injury (Tamarin, 1971 a,b; Leake et al, 1974;Leeb, 1978;Sans and Galanti, 1979).…”

Section: Activities During Developmentmentioning

confidence: 99%

Salivary Glands: A Paradigm for Diversity of Gland Development

Denny

Ball

Redman

1997

Critical Reviews in Oral Biology & Medicine

177

171

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The major salivary glands of mammals are represented by three pairs of organs that cooperate functionally to produce saliva for the oral cavity. While each type of gland produces a signature secretion that complements the secretions from the other glands, there is also redundancy as evidenced by secretion of functionally similar and, in some cases, identical products in the three glands. This, along with their common late initiation of development, in fetal terms, their similarities in developmental pattern, and their proximate sites of origin, suggests that a common regulatory cascade may have been shared until shortly before the onset of overt gland development. Furthermore, occasional ectopic differentiation of individual mature secretory cells in the wrong" gland suggests that control mechanisms responsible for the distinctive cellular composition of each gland also share many common steps, with only minor differences providing the impetus for diversification. To begin to address this area, we examine here the origins of the salivary glands by reviewing the expression patterns of several genes with known morphogenetic potential that may be involved based on developmental timing and location. The possibility that factors leading to determination of the sites of mammalian salivary gland development might be homologous to the regulatory cascade leading to salivarv gland formation in Drosophila is also evaluated. In a subsequent section, cellular phenotypes of neonatal and adult glands are compared and evaluated for insights into the mechanisms and lineages leading to cellular diversification. Finally, the phenomena of proliferation, repair, and regeneration in adult salivary glands are reviewed, with emphasis on the extent to which the cellular diversity is reversible and which cell type other than stem cells has the ability to redifferentiate into other cell types.

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“…Another fact worth mentioning was the relatively low cell accumulation rate in the intercalated ducts compartment during postnatal development of the mouse parotid glands, since several autoradiographic studies, using H 3 -thymidine labeling, have shown that the intercalated ducts of the rat parotid glands 17 , the submandibular glands of the rat 2 and mouse 14 , and the rat sublingual glands 18 exhibit very high proliferation rates during postnatal development, which are significantly higher than that of the striated ducts. However, despite the high proliferation rates observed for these glands, the intercalated duct cell population showed a markedly lower growth rate than the striated ducts, i.e., the accumulation of new cells in the intercalated duct compartment during the first months of life was lower than in the striated duct compartment.…”

Section: Discussionmentioning

confidence: 99%

Morphometric study of the postnatal growth of the parotid gland of the mouse

Ribeiro¹,

Sottovia

Cestari³

et al. 2006

Braz. oral res.

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ABSTRACT:The growth of the mouse parotid glands during 7 and 35 days of postnatal life was studied by morphometric methods. The mass of the gland, the volume of each morphological compartment, and the cell number in each compartment were evaluated. The data obtained for each evaluated dimension were adjusted by an exponential equation, of the type Y = a.e K.X , thus permitting the calculation of their mean duplication time (T D ), i.e., an estimation of their growth rate. Analysis of the results showed a marked 1,424% increase in the gland mass during the whole studied period, with T D = 7.10 days. This growth occurred by increases in absolute volume of acini, intercalated ducts, striated ducts, excretory ducts and stroma, with percentual increases of 3,048%, 417%, 2,662%, 2,594% and 367%, respectively, and T Ds of 5.62, 11.71, 5.55, 5.47 and 14.45 days, respectively. Analysis of the cell number growth in each compartment showed increases of 1,904%, 285%, 1,228%, 1,090% and 286%, respectively, and T Ds of 6.62, 20.40, 7.19, 7.26 and 14.51 days, respectively. Based on the present results, we concluded that the growth of the mouse parotid glands from day 7 to day 35 of age occurred by intense cell accumulation, mainly in the acini, striated ducts and excretory ducts, with a growth rate sensibly higher than that of the intercalated ducts and stroma. DESCRIPTORS: Parotid gland; Growth and embryonic development; Regression analysis; Histology; Animals. RESUMO:O crescimento das glândulas parótidas do camundongo durante 7 e 35 dias de vida pós-natal foi estudado por métodos morfométricos. A massa glandular, o volume de cada compartimento morfológico e o número de células em cada compartimento foram avaliados. Os dados obtidos para cada dimensão avaliada foram ajustados por equação exponencial, tipo Y = a.e k.x , permitindo o cálculo do seu tempo de duplicação médio (T D ), ou seja, uma estimativa da sua velocidade de crescimento. A análise dos resultados mostrou a ocorrência de um marcante aumento de massa glandular no período estudado de 1.424%, com T D = 7,10 dias. Esse crescimento glandular ocorreu por aumentos nos volumes absolutos dos ácinos, dos ductos intercalares, dos ductos estriados, dos ductos excretores e do estroma, com aumentos percentuais de, respectivamente, 3.048%, 417%, 2.662%, 2.594% e 367%, e T Ds de 5,62, 11,71, 5,55, 5,47 e 14,45 dias. A análise da evolução do número de células em cada compartimento demonstrou aumentos de, respectivamente, 1.904%, 285%, 1.228%, 1.090% e 286% e T Ds de 6,62, 20,40, 7,19, 7,26 e 14,51 dias. Baseados nos resultados aqui obtidos, concluímos que o crescimento das glândulas parótidas do camundongo entre os dias 7 e 35 de idade ocorre por intenso acúmulo de células, principalmente nos ácinos e nos ductos estriados e excretores, com uma velocidade de crescimento sensivelmente maior que nos ductos intercalares e no estroma.

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Cell Proliferation, Differentiation and Transformation in the Rat Submandibular Gland during Early Postnatal Growth. A Quantitative and Morphological Study

Cited by 60 publications

References 38 publications

Ultrastructural Studies on Developing Parotid Gland of the Rat at Early Postnatal Periods

Ultrastructural Studies on Developing Parotid Gland of the Rat at Early Postnatal Periods

Salivary Glands: A Paradigm for Diversity of Gland Development

Morphometric study of the postnatal growth of the parotid gland of the mouse

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