2019
DOI: 10.1146/annurev-cellbio-100818-125427
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Abstract: This is the story of someone who has been fortunate to work in a field of research where essentially nothing was known at the outset but that blossomed with the discovery of profound insights about two basic biological processes: cell motility and cytokinesis. The field started with no molecules, just a few people, and primitive methods. Over time, technological advances in biophysics, biochemistry, and microscopy allowed the combined efforts of scientists in hundreds of laboratories to explain mysterious proc… Show more

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Cited by 13 publications
(14 citation statements)
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References 184 publications
(154 reference statements)
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“…Since our CLEM approach grants access to the cytosolic content of spines (Fig 3A), we quantified the occurrence of SA, a complex stacked membrane specialization of smooth endoplasmic reticulum (SER), which contributes to calcium signaling, integral membrane protein trafficking, local protein synthesis, and synaptic plasticity [12][13][14]79,80]. In basal dendrites, about 54% of spines contained an SA (Fig 3B), which is substantially higher than previous reports in the mature hippocampus [12,81].…”
Section: Plos Biologymentioning
confidence: 87%
See 1 more Smart Citation
“…Since our CLEM approach grants access to the cytosolic content of spines (Fig 3A), we quantified the occurrence of SA, a complex stacked membrane specialization of smooth endoplasmic reticulum (SER), which contributes to calcium signaling, integral membrane protein trafficking, local protein synthesis, and synaptic plasticity [12][13][14]79,80]. In basal dendrites, about 54% of spines contained an SA (Fig 3B), which is substantially higher than previous reports in the mature hippocampus [12,81].…”
Section: Plos Biologymentioning
confidence: 87%
“…The size of the spine head correlates with the size of the ePSD and the strength of synaptic transmission [7][8][9][10][11]. In addition to the ePSD, spines contain ribosomes, which mediate local protein synthesis, and endosomes, which play a critical role in membrane and receptor trafficking [12,13]. The largest spines often contain a spine apparatus (SA), which contributes to calcium signaling and synaptic plasticity [12,14], and some spines, especially in the upper layers of the cortex, also house an inhibitory postsynaptic specialization [15].…”
Section: Introductionmentioning
confidence: 99%
“…Despite our understanding of how a multitude of extracellular stimuli trigger pathways that lead to actin polymerization/depolymerization, and the detailed molecular mechanism of local actin nucleation (Pollard, 2019), some challenges remain to be addressed. There is a need to learn about the mechanisms that control newly assembled F-actin into higher order structures such as stress fibers, filopodia, and other bundles including short filaments near membrane-resident receptors.…”
Section: Regulation Of the Actin Cytoskeleton By Cctmentioning
confidence: 99%
“…Imaging living cells in vitro is crucial in deciphering the biochemical mechanisms underlying complex cellular activity such as cell motility 1 , differentiation 2 , membrane trafficking 3 , and cell-to-cell communication 4 . Our knowledge about the ultra-structure of a cell is almost exclusively derived from high-resolution electron microscopy (EM) on fixed and sectioned cells.…”
Section: Introductionmentioning
confidence: 99%