Cell Migration from Baby to Mother

Dawe, Gavin S.; Tan, Xin; Xiao, Zhicheng

doi:10.4161/cam.4082

Cited by 75 publications

(49 citation statements)

References 93 publications

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“…It is not known how PAPCs transfer to the mothers, but the most intuitive route would be via the fetal cord bloodplacenta-maternal blood axis [30]. This hypothesis finds some support in the presence of fetal cells in the maternal blood circulation at about E11-14.…”

Section: Papcs In Maternal Brainmentioning

confidence: 99%

Pregnancy-Associated Progenitor Cells Differentiate and Mature into Neurons in the Maternal Brain

Zeng

Tan

Yeo

et al. 2010

Stem Cells and Development

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Bidirectional cell trafficking between fetus and mother during pregnancy is a well-established phenomenon observed in placental vertebrates including humans. Although studies have shown that transmigratory fetal cells, also termed pregnancy-associated progenitor cells (PAPCs), can integrate into multiple maternal organs, the integration, long-term survival, and differentiation of PAPCs in the brain has not been extensively studied. Using a murine model of fetomaternal microchimerism, we show that PAPCs integrated and persisted in several areas of the maternal brain for up to 7 months postpartum. Besides expressing neural stem cell or immature neuronal markers, PAPCs were observed to express mature neuronal markers, indicating that PAPCs adopted a neuronal fate. Further, PAPCs also displayed morphologically neuronal maturation by an increasing axonal/dendritic complexity over time. Therefore, PAPCs seem to undergo a molecular and morphological maturation program similar to that observed during adult neurogenesis. We provide evidence that neuronal gene expression of PAPCs was not a consequence of cell fusion with maternal neurons. In addition, in mothers with experimentally induced Parkinson's disease (PD), the frequency of PAPCs within the hippocampus initially increased whereas long-term presence of PAPCs was compromised. Also, the spatial distribution of PAPCs within the hippocampus was altered in mothers with PD. Thus, the disease context influenced the initial attraction, long-term survival, and spatial distribution of PAPCs, which may have wider implications on cell replacement strategies in human neurodegenerative diseases such as PD.

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Section: Papcs In Maternal Brainmentioning

confidence: 99%

Pregnancy-Associated Progenitor Cells Differentiate and Mature into Neurons in the Maternal Brain

Zeng

Tan

Yeo

et al. 2010

Stem Cells and Development

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“…The precise mechanism by which this occurs is still unclear. Some of the proposed mechanisms include micro-traumatic rupture of the placental blood channels or leakage of placentauterine barrier, adhesion and transmigration across high endothelial venulae, and other [24,25].…”

Section: Fetal Cells and Cell-free Dna In Prenatal Diagnosticsmentioning

confidence: 99%

The Cell-Free Dna Detection and Analysis as the New Non-Invasive Prenatal Diagnostics Option

Milojkovic

Milenković

2017

FU Med Biol

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“…45 Such trafficking has been reported for trophoblasts, and also for a great variety of hematopoietic, lymphoid and mesenchymal cell types. 46 The implications of such cell migration are unclear, with issues related to a putative role in autoimmunity, and cancer development, unresolved. 47,48 What is well recognized is the transmission of fetal derived malignancy to the mother, and vice versa.…”

Section: Implications For Cancer Biology and Relevance To Human Cancermentioning

confidence: 99%

Tasmanian devil facial tumor disease: Insights into reduced tumor surveillance from an unusual malignancy

O’Neill¹

2010

Intl Journal of Cancer

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Tasmanian devil facial tumor disease (DFTD) is a highly aggressive cancer involving the facial tissues that currently presents a serious extinction risk for the Tasmanian devil population. Although the histogenesis is uncertain, an origin from a neural crest cell‐lineage is considered likely. Epidemiological, cytogenetic and immunological data all support the premise that DFTD arose from a single tumor clone from an individual diseased animal, and is being transmitted between individual animals as a tumor “allograft” by biting during social interaction. The spread of this cancer throughout the species is believed to be facilitated by a reduced MHC diversity, possibly as a result of an evolutionary bottleneck. The pathogenesis of DFTD has some similarities with certain human cancers, including donor‐recipient tumor transmission, which may complicate organ transplantation, and certain forms of malignancy at the maternal/fetal interface. The natural history and pathology of DFTD, and the data describing this highly unusual tumor biology are discussed.

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Cell Migration from Baby to Mother

Cited by 75 publications

References 93 publications

Pregnancy-Associated Progenitor Cells Differentiate and Mature into Neurons in the Maternal Brain

Pregnancy-Associated Progenitor Cells Differentiate and Mature into Neurons in the Maternal Brain

The Cell-Free Dna Detection and Analysis as the New Non-Invasive Prenatal Diagnostics Option

Tasmanian devil facial tumor disease: Insights into reduced tumor surveillance from an unusual malignancy

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