2018
DOI: 10.3390/cancers10100357
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Background: Breast (BrC), colorectal (CRC) and lung (LC) cancers are the three most common and deadly cancers in women. Cancer screening entails an increase in early stage disease detection but is hampered by high false-positive rates and overdiagnosis/overtreatment. Aberrant DNA methylation occurs early in cancer and may be detected in circulating cell-free DNA (ccfDNA), constituting a valuable biomarker and enabling non-invasive testing for cancer detection. We aimed to develop a ccfDNA methylation-based tes… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

4
40
0

Year Published

2019
2019
2023
2023

Publication Types

Select...
8

Relationship

3
5

Authors

Journals

citations
Cited by 44 publications
(44 citation statements)
references
References 55 publications
(98 reference statements)
4
40
0
Order By: Relevance
“…These include markers or marker sets to detect e.g. lung [30][31][32][33][34][35], breast [12,13], colorectal [36,37] or pancreatic [38] cancers. A few DNA methylation cancer biomarkers are already in clinical use, e.g.…”
Section: Introductionmentioning
confidence: 99%
“…These include markers or marker sets to detect e.g. lung [30][31][32][33][34][35], breast [12,13], colorectal [36,37] or pancreatic [38] cancers. A few DNA methylation cancer biomarkers are already in clinical use, e.g.…”
Section: Introductionmentioning
confidence: 99%
“…GATA5 me , SFRP2 me , ITGA4 me , SHOX2 me and SEPT9 me levels were also associated with tumors' histological grade, TNM stage and lymph node metastasis [141,156], whereas GATA5 me also associated with large tumor size [141]. Furthermore, APC me, SEPT9 me , SHOX2 me and SOX17 me levels were also shown to be significantly higher in female patients with metastatic disease [36], whereas higher RARB2 me , SEPT9 me and SOX17 me levels were disclosed in metastatic CRC male patients [46].…”
Section: Prognosis Prediction and Monitoringmentioning
confidence: 92%
“…Indeed, SHOX2 me detected with higher sensitivity small cell lung cancer (SCLC) (80%) and lung squamous cell carcinoma (LUSC) (63%) than lung adenocarcinoma (LUAD) (39%) [37]. Similarly, DCLK1 me was more frequent in SCLC than NSCLC [42], and our research team recently reported higher APC me and RARβ2 me levels in SCLC compared to LUAD, in females [36]. Conversely, SEPT9 me was more frequent in NSCLC (53%) than in SCLC (26%) [43].…”
Section: Screening and Diagnosismentioning
confidence: 94%
See 1 more Smart Citation
“…Specifically, early onset detection of three of the most frequent cancers in men-colorectal, prostate and lung-is possible through non-invasive identification of aberrant DNA methylation at the promoter region of oncogenes and tumour-suppressor genes [87]. Analogically, cell-free DNA methylation-based tests are currently being developed for early onset detection of equivalent common cancer in women-colorectal, lung and breast cancers [88]. Genome-wide association studies (GWASs) enabled description of heritable epigenetic mechanisms, their effect on signalling pathways and reversible alterations in various types of cancers, currently recognized as their hallmarks [89].…”
Section: Cancer Research and Anti-cancer Therapy-living In The Shadowmentioning
confidence: 99%