2021
DOI: 10.1161/circresaha.120.318200
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Abstract: Rationale: Defects in the morphogenesis of the 4th pharyngeal arch arteries (PAAs) give rise to lethal birth defects. Understanding genes and mechanisms regulating PAA formation will provide important insights into the etiology and treatments for congenital heart disease. Objective: Cell-ECM interactions play essential roles in the morphogenesis of PAAs and their derivatives, the aortic arch artery (AAA) and its major branches; however, their specific f… Show more

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Cited by 16 publications
(14 citation statements)
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“…Matrix stiffness is one of the important features of the ECM. These results suggest that stiffness change could affect cell-cell interactions as well as cell-ECM interactions [38] [39], which in turn may disrupt vessel integrity and endothelial barrier function.…”
Section: Discussionmentioning
confidence: 93%
“…Matrix stiffness is one of the important features of the ECM. These results suggest that stiffness change could affect cell-cell interactions as well as cell-ECM interactions [38] [39], which in turn may disrupt vessel integrity and endothelial barrier function.…”
Section: Discussionmentioning
confidence: 93%
“…Lineage-dependent differences are retained in cultured VSMCs with respect to the expression of extracellular matrix proteins and contractile proteins, modulators of angiotensin II signaling, and responsiveness to TGF-β [476][477][478][479][480][481]. Although regional differences also apply to endothelial cells, the role of embryonic origin is less clear [482][483][484][485][486]. More recently, lineage-specific differences have been observed in iPS-derived VSMCs differentiated from mesoderm and neural crest progenitors [467,[487][488][489][490].…”
Section: Developmental and Phenotypic Heterogeneitymentioning
confidence: 99%
“…Subsequent analysis revealed that vascular plexus ECs migrate against blood flow and coalesce to form major vessels as cardiac output (and, hence, shear stress) increases (Udan et al, 2013;Garcia and Larina, 2014). Likewise, in the embryonic pharyngeal arches at mid-gestation, the pharyngeal arch artery connected to the outflow tract of the heart is formed via vascular remodeling that transforms a non-hierarchical primordial vascular plexus into a major artery (Wang et al, 2017;Warkala et al, 2021), a process during which hemodynamic forces possibly play a role.…”
Section: Acquisition Of Arterial Fate In Vascular Remodeling During Angiogenesis -Coordination Of Arterial Specification and Sproutingmentioning
confidence: 99%