volume 8, issue 9, P2100-2126 2016
DOI: 10.18632/aging.101052
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Matthias Dottermusch, Theresa Lakner, Tobias Peyman, Marinella Klein, Gerd Walz, Elke Neumann-Haefelin

Abstract: Recent studies have revealed a variety of genes and mechanisms that influence the rate of aging progression. In this study, we identified cell cycle factors as potent regulators of health and longevity in C. elegans. Focusing on the cyclin-dependent kinase 2 (cdk-2) and cyclin E (cye-1), we show that inhibition of cell cycle genes leads to tolerance towards environmental stress and longevity. The reproductive system is known as a key regulator of longevity in C. elegans. We uncovered the gonad as the central o…

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