2016
DOI: 10.18632/aging.101052
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Abstract: Recent studies have revealed a variety of genes and mechanisms that influence the rate of aging progression. In this study, we identified cell cycle factors as potent regulators of health and longevity in C. elegans. Focusing on the cyclin-dependent kinase 2 (cdk-2) and cyclin E (cye-1), we show that inhibition of cell cycle genes leads to tolerance towards environmental stress and longevity. The reproductive system is known as a key regulator of longevity in C. elegans. We uncovered the gonad as the central o… Show more

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Cited by 8 publications
(7 citation statements)
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References 67 publications
(104 reference statements)
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“…Based on our findings, Paramecium could achieve this unbalanced signalling by down-regulating the nutrient-sense signaling and thus cell growth. Similar mechanisms could shape similar responses in C. elegans [80,89]. At any rate, because of the deep evolutionary conservation of the stress response and sex molecular machineries, our study urges caution over swiftly invoking genetic diversity to explain increased stress tolerance in sexually produced offspring.…”
Section: Discussionmentioning
confidence: 81%
“…Based on our findings, Paramecium could achieve this unbalanced signalling by down-regulating the nutrient-sense signaling and thus cell growth. Similar mechanisms could shape similar responses in C. elegans [80,89]. At any rate, because of the deep evolutionary conservation of the stress response and sex molecular machineries, our study urges caution over swiftly invoking genetic diversity to explain increased stress tolerance in sexually produced offspring.…”
Section: Discussionmentioning
confidence: 81%
“…cct-4 encodes for a chaperonin required for SKN-1–dependent transcription of a putative glutathione-requiring prostaglandin D synthase, gst-4 (Kahn et al, 2008). The gene cdk-2 encodes for a cyclin-dependent kinase, which has been recently implicated in regulating stress responses and longevity by inhibiting cell cycle machinery (Dottermusch et al, 2016). A germ line–specific translation initiation factor is encoded by iff-1 , which was shown to regulate life span in the first genome-wide functional screen for longevity genes (Hamilton et al, 2005).…”
Section: Resultsmentioning
confidence: 99%
“…Among 13 discovered longevity-promoting chemicals, four (AT 7519, alvocidib, CGP-60474, and PHA-793887) are indicated as cyclin-dependent kinase (CDK) inhibitors. Interestingly, previous studies have shown inhibition on CDK-2 resulted in tolerance towards environmental stress and promoted anti-aging in Caenorhabditis elegans [14,15]. Moreover, "BI-2536" inhibits tumor growth in vivo by inducing apoptosis on cancer cells as an inhibitor of polo-like kinase 1 [16].…”
Section: Repurposed Drugsmentioning
confidence: 99%