2006
DOI: 10.1002/dvdy.20844
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Abstract: Animals use diverse strategies to specify tissue lineages during development. A common strategy is to partition maternally supplied and localized lineage determinants into progenitor cells. The mouse embryo appears to use a different, more regulative strategy to specify the first three lineages: the epiblast (EPI: future embryo), the trophectoderm (TE: future placenta), and the primitive endoderm (PE: future yolk sac). These lineages are specified during two successive differentiation steps leading to formatio… Show more

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Cited by 262 publications
(243 citation statements)
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References 94 publications
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“…Mammalian morula is transformed to the blastocyst through delamination. In mammalian embryogenesis, cell fate is specified at the 8-cell stage by the establishment of cell polarity (Yamanaka et al 2006;Johnson 2009) along the radius of early morula. Subsequent cell divisions lead to symmetric or asymmetric distribution of polarity information, based on the angle of cell division.…”
Section: Blastulation: Orientable Surfacementioning
confidence: 99%
“…Mammalian morula is transformed to the blastocyst through delamination. In mammalian embryogenesis, cell fate is specified at the 8-cell stage by the establishment of cell polarity (Yamanaka et al 2006;Johnson 2009) along the radius of early morula. Subsequent cell divisions lead to symmetric or asymmetric distribution of polarity information, based on the angle of cell division.…”
Section: Blastulation: Orientable Surfacementioning
confidence: 99%
“…Aux trois lignages cellulaires présents à l'implantation, l'Epi, le Tr et l'EPr, correspondent trois modèles in vitro de cellules souches [3]. Les trois types de cellules souches sont isolés à partir de blastocystes (E3,5).…”
Section: Cellules Souches Issues Du Blastocysteunclassified
“…ces molécules au cours des divisions symétriques et asymétriques ainsi que leur localisation baso-laté-rale ou apicale maintiennent la polarité des cellules externes [2,3]. Par exemple, lorsque l'aPKC ou ParD3, exprimées au pôle apical des cellules polarisées, sont inactivées dans certaines cellules, ces cellules ont tendance à se localiser à l'intérieur de l'embryon [12].…”
Section: Revuesunclassified
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“…Le la masse cellulaire interne (MCI) qui sera à l'origine du futur embryon, le trophectoderme, futur placenta, et l'endoderme primitif qui constituera avec le mésoderme extraembryonnaire le futur sac vitellin. L'établissement de ces lignages est finement régulé et plusieurs mécanismes expliquant l'apparition et le maintien des premières différenciations cellulaires ont été proposés [1]. Chez les métazoaires, la voie de signalisation Notch est un mode fondamental de communication entre cellules voisines [2,3].…”
unclassified