1994
DOI: 10.1055/s-2007-1016491 View full text |Buy / Rent full text
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Abstract: Since the introduction of the proteinase inhibitor aprotinin in cardiac surgery, a strong increase of the activated clotting time (ACT) during the extracorporeal circulation phase (ECC) was reported in many clinical studies, but with a lack of correlation between ACT and heparin concentration. In searching for a cause of this inconsistency we investigated different surface activators of the ACT in a clinical study. During ECC ACT was measured in parallel, using a Hemochron device and corresponding tubes (nomin… Show more

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“…All available devices have acceptable reproducibility, but reference and therapeutic ACT ranges vary considerably. 21,26,27 Therefore, every ACT test should be regarded as unique.…”
Section: Actmentioning
“…21,25 Another example is aprotinin, which affects Celitebased ACT but not kaolin-based ACT. 26 Venous ACT was found to be slightly but significantly greater than arterial ACT in 1 prospective study that sampled arterial and venous blood in 48 patients undergoing PCI. 35 This difference, however, did not affect the complication rate or the amount of heparin used during the procedure.…”
mentioning
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“…Activated clotting time values obtained in the presence of aprotinin can yield substantial variability with different activators [3,4]. Celite ACT (SonACT) values are prolonged in vitro with commonly used doses of aprotinin during heparin anticoagulation [3,5].…”
Section: Introductionmentioning
“…Celite ACT (SonACT) values are prolonged in vitro with commonly used doses of aprotinin during heparin anticoagulation [3,5]. The impact on the kaolin is less, and thus, kaolin ACT (kACT) is an alternative to the SonACT [2][3][4][5]. However, even kACT is significantly prolonged in the presence of aprotinin [5].…”
Section: Introductionmentioning