Celecoxib, a Cyclooxygenase 2 Inhibitor as a Potential Chemopreventive to UV-Induced Skin Cancer

Orengo, Ida; Gerguis, Janette; Phillips, Rhea M.; Guevara, Adrian; Lewis, Alan T.; Black, Homer S.

doi:10.1001/archderm.138.6.751

Cited by 92 publications

(60 citation statements)

References 39 publications

(36 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Accumulated data support the idea that an increased expression of COX-2 plays a significant role in different disease processes, including several cancers (3)(4). Anticancer effects are also reported for COX-2 inhibitors in adenocarcinoma of the colon, lung cancer, intestinal polyposis (5-6) and in skin cancers (7)(8).…”

Section: Introductionmentioning

confidence: 65%

Influence of Oleic Acid on the Rheology and in Vitro Release of Lumiracoxib from Poloxamer Gels

2010

View full text Add to dashboard Cite

-Purpose. Transdermal delivery of anti-inflammatory lumiracoxib (LM) could be an interesting strategy to avoid the side effects associated with systemic delivery, but it is ineffective due to the drug poor skin penetration. We have investigated the effects of oleic acid (OA), a lipid penetration enhancer, on the in vitro release of LM from poloxamer-based delivery systems (PBDS). The rheological behavior (shear rate dependent viscosity) and gelation temperature through measurements of optimal sol-gel transition temperatures (T sol-gel ) were also carried out in these systems. Methods. In vitro release studies of LM from PBDS were performed using cellulose acetate as artificial membrane mounted in a diffusion system. The amount of LM released was divided by exposition area (µg/cm 2 ) and these values were plotted as function of the time (h). The flux of the drug across the membrane (J) was calculated from the slope of the linear portion of the plot and expressed as µg/cm 2 /h. The determination of viscosity was carried out at different shear rates (γ) between 0.1-1000 S -1 using a parallel plate rheometer. Oscillatory measurements using a cone-plate geometry rheometer surrounded by a double jacket with temperature varying 4-40°C, was used in order to determine T sol-gel . Results. Increase of both polymer and OA concentrations increases the viscosity of the gels and consequently reduces the in vitro LM release from the PBDS, mainly for gels containing OA at 10.0% (w/w) compared to other concentrations of the penetration enhancer. T sol-gel transition temperature was decreased by increasing viscosity; in some cases the formulation was already a gel at room temperature. Rheological studies showed a pseudoplastic behavior, which facilitates the flow and improves the spreading characteristics of the formulations. Conclusions. Taken together, the results showed that poloxamer gels are good potential delivery systems for LM, leading to a sustained release, and also have appropriate rheological characteristics.

show abstract

Section: Introductionmentioning

confidence: 65%

Influence of Oleic Acid on the Rheology and in Vitro Release of Lumiracoxib from Poloxamer Gels

2010

View full text Add to dashboard Cite

show abstract

“…12,13 A decrease in the formation of UV-induced skin tumors in mice that received celecoxib (89% reduction) or indomethacin (78% reduction) was observed. 37,38 A reduction in more than 50% of UVR-induced skin tumors in naked mice receiving nimesulide -a selective inhibitor of COX-2 -was also observed. 39 Additionally, celecoxib inhibited the growth of melanoma cells, even in strains not expressing COX-2.…”

Section: Discussionmentioning

confidence: 85%

Oral acetylsalicylic acid and prevalence of actinic keratosis

Schmitt

Miot

2014

Rev. Assoc. Med. Bras.

View full text Add to dashboard Cite

show abstract

“…14,50 In addition, in murine models of skin carcinogenesis, it has been shown that administration of NSAIDs, especially selective Cox-2 inhibitors, reduces the prevalence and multiplicity of UV light-induced neoplasms 9,51,52 strongly implying direct involvement of Cox-2 in cutaneous carcinogenesis. Furthermore, specific inhibitors of Cox-2 such as celecoxib have been shown not only to decrease tumorigenesis and increase tumor latency in hairless mice models, 53 but also to decrease tumor growth in hairless mice with pre-existing UVB-induced tumors. 54 However, chronic long-term use of these medications has been associated with a number, in some cases life-threatening, side effects including decreased gastric protection that may lead to gastrointestinal bleeding, impairment of renal function, and inhibition of platelet aggregation 55 and most recently, increased incidence of myocardial infarction in elderly.…”

Section: Discussionmentioning

confidence: 99%

Polypodium leucotomos Extract Decreases UV-Induced Cox-2 Expression and Inflammation, Enhances DNA Repair, and Decreases Mutagenesis in Hairless Mice

Zattra

Coleman

Arad

et al. 2009

The American Journal of Pathology

View full text Add to dashboard Cite

mice were fed for 10 days with PL (300 mg/kg) or vehicle then UV-irradiated, once. By 24 hours, UVinduced Cox-2 levels were increased in vehicle-fed and PL-fed mice, whereas by 48 and 72 hours, Cox-2 levels were four-to fivefold lower in PL-fed mice (P < 0.05). p53 expression/activity was increased in PL-fed versus vehicle-fed then UV-irradiated mice. UV-induced inflammation was decreased in PL-fed mice, as shown by ϳ60% decrease (P < 0.001) in neutrophil infiltration at 24 hours, and macrophages by ϳ50% (<0.02) at 24 and 48 hours. By 72 hours, 54 ؎ 5% cyclobutane pyrimidine dimers remained in vehiclefed versus 31 ؎ 5% in PL-fed skin (P < 0.003). The number of 8-hydroxy-2-deoxyguanosine-positive cells were decreased before UV irradiation by ϳ36% (P < 0.01), suggesting that PL reduces constitutive oxidative DNA damage. By 6 and 24 hours, the number of 8-hydroxy-2-deoxyguanosine-positive cells were ϳ59% (P < 0.01) and ϳ79% (P < 0.03) lower in PL-fed versus vehicle-fed mice. Finally, UV-induced mutations in PL-fed-mice were decreased by ϳ25% when assessed 2 weeks after the single UV exposure. These data demonstrate that PL extract supplementation affords the following photoprotective effects: p53 activation and reduction of acute inflammation via Cox-2 enzyme inhibition, increased cyclobutane pyrimidine dimer removal, and reduction of oxidative DNA damage.

show abstract

Celecoxib, a Cyclooxygenase 2 Inhibitor as a Potential Chemopreventive to UV-Induced Skin Cancer

Cited by 92 publications

References 39 publications

Influence of Oleic Acid on the Rheology and in Vitro Release of Lumiracoxib from Poloxamer Gels

Influence of Oleic Acid on the Rheology and in Vitro Release of Lumiracoxib from Poloxamer Gels

Oral acetylsalicylic acid and prevalence of actinic keratosis

Polypodium leucotomos Extract Decreases UV-Induced Cox-2 Expression and Inflammation, Enhances DNA Repair, and Decreases Mutagenesis in Hairless Mice

Contact Info

Product

Resources

About