2019
DOI: 10.1371/journal.pbio.3000499
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Abstract: The onset of sexual maturity involves dramatic changes in physiology and gene expression in many animals. These include abundant yolk protein production in egg-laying species, an energetically costly process under extensive transcriptional control. Here, we used the model organism Caenorhabditis elegans to provide evidence for the spatiotemporally defined interaction of two evolutionarily conserved transcription factors, CEH-60/PBX and UNC-62/MEIS, acting as a gateway to yolk protein production. Via proteomics… Show more

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Cited by 18 publications
(36 citation statements)
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“…While ceh-60 is not expressed in the body wall muscle of C . elegans , which comprises the largest muscle system in the animal, ceh-60 is distinctly expressed in the smaller pharyngeal muscle system [ 10 ], indicating a possible role for ceh-60 in this tissue. As “regulation of muscle contraction” is one of the most overrepresented biological processes among CEH-60 DamID targets, we speculate that CEH-60 could be involved in contraction of the pharynx, which is indispensable for feeding [ 61 ].…”
Section: Resultsmentioning
confidence: 99%
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“…While ceh-60 is not expressed in the body wall muscle of C . elegans , which comprises the largest muscle system in the animal, ceh-60 is distinctly expressed in the smaller pharyngeal muscle system [ 10 ], indicating a possible role for ceh-60 in this tissue. As “regulation of muscle contraction” is one of the most overrepresented biological processes among CEH-60 DamID targets, we speculate that CEH-60 could be involved in contraction of the pharynx, which is indispensable for feeding [ 61 ].…”
Section: Resultsmentioning
confidence: 99%
“…We performed DamID on both young adult animals and L2 larvae in order to get a more dynamic view of how CEH-60 gene targets may change when its expression pattern shifts with respect to development, i.e. from limited to the neurons and PM6 during early larval stages to also including intestinal cells in L4 and adult stages [10]. Applying the same approach as for young adult animals, we found 587 candidate CEH-60 targets in L2 DNA (S2 Table).…”
Section: Developmental Expression Shift Of Ceh-60 Targetsmentioning
confidence: 99%
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