Ceftriaxone in Amyotrophic Lateral Sclerosis

An Overview of Target Specific Neuro-Protective and Neuro-Restorative Strategies

“…Controversial but mainly negative data on the efficacy of cephalosporins in ALS have been published (Norris, 1994). However, gabapentin, lamotrigine, and topiramate, and other agents known to alter glutamate synthesis and release, appeared promising in pre-clinical studies (Maragakis et al, 2003) but showed no benefit in ALS patients (Cudkowicz et al, 2003).…”

An Overview of Target Specific Neuro-Protective and Neuro-Restorative Strategies

“…Controversial but mainly negative data on the efficacy of cephalosporins in ALS have been published (Norris, 1994). However, gabapentin, lamotrigine, and topiramate, and other agents known to alter glutamate synthesis and release, appeared promising in pre-clinical studies (Maragakis et al, 2003) but showed no benefit in ALS patients (Cudkowicz et al, 2003).…”

An Overview of Target Specific Neuro-Protective and Neuro-Restorative Strategies

“…Controversial but mainly negative data on the efficacy of cephalosporins in ALS have been published (Norris, 1994). However, gabapentin, lamotrigine, and topiramate, and other agents known to alter glutamate synthesis and release, appeared promising in pre-clinical studies (Maragakis et al, 2003) but showed no benefit in ALS patients (Cudkowicz et al, 2003).…”

An Overview of Target Specific Neuro-Protective and Neuro-Restorative Strategies

“…Controversial but mainly negative data on the efficacy of cephalosporins in ALS have been published (Norris, 1994). However, gabapentin, lamotrigine, and topiramate, and other agents known to alter glutamate synthesis and release, appeared promising in pre-clinical studies (Maragakis et al, 2003) but showed no benefit in ALS patients (Cudkowicz et al, 2003).…”