Cefotaxime vs Penicillin G for Acute Neurologic Manifestations in Lyme Borreliosis

Epidemiology and Clinical Manifestations of Lyme Borreliosis in Childhood

“…None of these children ever showed exclusively IgG antibodies in CSF. These results are in marked contrast to the results of most other studies of neuroborreliosis for which the diagnostic criteria for neuroborreliosis was the detection of specific IgG antibodies (2,107,164,235,274,350). Because the IgM antibodies are five times the molecular weight of IgG antibodies, the permeability of the blood-brain barrier is less important for detection of IgM antibodies in CSF than for IgG antibodies in CSF.…”

“…The present study differs considerably from other studies of neuroborreliosis with respect to antibody test results, as in most other studies it was IgG antibodies which were the basis on which a diagnosis was made (2,107,164,235,274,350). However, as these other studies mostly investigated adult cases, it is entirely possible that the difference in the frequency of positive IgM and IgG antibody tests could be explained by the varying length of illness in the two different kinds of patient samples.…”

Epidemiology and Clinical Manifestations of Lyme Borreliosis in Childhood

“…None of these children ever showed exclusively IgG antibodies in CSF. These results are in marked contrast to the results of most other studies of neuroborreliosis for which the diagnostic criteria for neuroborreliosis was the detection of specific IgG antibodies (2,107,164,235,274,350). Because the IgM antibodies are five times the molecular weight of IgG antibodies, the permeability of the blood-brain barrier is less important for detection of IgM antibodies in CSF than for IgG antibodies in CSF.…”

“…The present study differs considerably from other studies of neuroborreliosis with respect to antibody test results, as in most other studies it was IgG antibodies which were the basis on which a diagnosis was made (2,107,164,235,274,350). However, as these other studies mostly investigated adult cases, it is entirely possible that the difference in the frequency of positive IgM and IgG antibody tests could be explained by the varying length of illness in the two different kinds of patient samples.…”

Abstract

“…The present study differs considerably from other studies of neuroborreliosis with respect to antibody test results, as in most other studies it was IgG antibodies which were the basis on which a diagnosis was made (2,107,164,235,274,350). However, as these other studies mostly investigated adult cases, it is entirely possible that the difference in the frequency of positive IgM and IgG antibody tests could be explained by the varying length of illness in the two different kinds of patient samples.…”

“…None of these children ever showed exclusively IgG antibodies in CSF. These results are in marked contrast to the results of most other studies of neuroborreliosis for which the diagnostic criteria for neuroborreliosis was the detection of specific IgG antibodies (2,107,164,235,274,350). Because the IgM antibodies are five times the molecular weight of IgG antibodies, the permeability of the blood-brain barrier is less important for detection of IgM antibodies in CSF than for IgG antibodies in CSF.…”

“…Symptoms such as headaches or radicular pain, as well as psychopatho-ACTA PfiDIATR SUPPL 386 [ 1993) logical disturbances which had persisted for weeks or had recurred intermittently disappeared after only a few days of high-dose penicillin treatments. This same effect was reported for adults with neuroborreliosis (168,235,290).…”

Epidemiology and Clinical Manifestations of Lyme Borreliosis in Childhood

“…None of these children ever showed exclusively IgG antibodies in CSF. These results are in marked contrast to the results of most other studies of neuroborreliosis for which the diagnostic criteria for neuroborreliosis was the detection of specific IgG antibodies (2,107,164,235,274,350). Because the IgM antibodies are five times the molecular weight of IgG antibodies, the permeability of the blood-brain barrier is less important for detection of IgM antibodies in CSF than for IgG antibodies in CSF.…”

“…The present study differs considerably from other studies of neuroborreliosis with respect to antibody test results, as in most other studies it was IgG antibodies which were the basis on which a diagnosis was made (2,107,164,235,274,350). However, as these other studies mostly investigated adult cases, it is entirely possible that the difference in the frequency of positive IgM and IgG antibody tests could be explained by the varying length of illness in the two different kinds of patient samples.…”

Abstract

“…The present study differs considerably from other studies of neuroborreliosis with respect to antibody test results, as in most other studies it was IgG antibodies which were the basis on which a diagnosis was made (2,107,164,235,274,350). However, as these other studies mostly investigated adult cases, it is entirely possible that the difference in the frequency of positive IgM and IgG antibody tests could be explained by the varying length of illness in the two different kinds of patient samples.…”

“…None of these children ever showed exclusively IgG antibodies in CSF. These results are in marked contrast to the results of most other studies of neuroborreliosis for which the diagnostic criteria for neuroborreliosis was the detection of specific IgG antibodies (2,107,164,235,274,350). Because the IgM antibodies are five times the molecular weight of IgG antibodies, the permeability of the blood-brain barrier is less important for detection of IgM antibodies in CSF than for IgG antibodies in CSF.…”

“…Symptoms such as headaches or radicular pain, as well as psychopatho-ACTA PfiDIATR SUPPL 386 [ 1993) logical disturbances which had persisted for weeks or had recurred intermittently disappeared after only a few days of high-dose penicillin treatments. This same effect was reported for adults with neuroborreliosis (168,235,290).…”

Epidemiology and Clinical Manifestations of Lyme Borreliosis in Childhood

“…None of these children ever showed exclusively IgG antibodies in CSF. These results are in marked contrast to the results of most other studies of neuroborreliosis for which the diagnostic criteria for neuroborreliosis was the detection of specific IgG antibodies (2,107,164,235,274,350). Because the IgM antibodies are five times the molecular weight of IgG antibodies, the permeability of the blood-brain barrier is less important for detection of IgM antibodies in CSF than for IgG antibodies in CSF.…”

“…The present study differs considerably from other studies of neuroborreliosis with respect to antibody test results, as in most other studies it was IgG antibodies which were the basis on which a diagnosis was made (2,107,164,235,274,350). However, as these other studies mostly investigated adult cases, it is entirely possible that the difference in the frequency of positive IgM and IgG antibody tests could be explained by the varying length of illness in the two different kinds of patient samples.…”

Abstract

“…The present study differs considerably from other studies of neuroborreliosis with respect to antibody test results, as in most other studies it was IgG antibodies which were the basis on which a diagnosis was made (2,107,164,235,274,350). However, as these other studies mostly investigated adult cases, it is entirely possible that the difference in the frequency of positive IgM and IgG antibody tests could be explained by the varying length of illness in the two different kinds of patient samples.…”

“…None of these children ever showed exclusively IgG antibodies in CSF. These results are in marked contrast to the results of most other studies of neuroborreliosis for which the diagnostic criteria for neuroborreliosis was the detection of specific IgG antibodies (2,107,164,235,274,350). Because the IgM antibodies are five times the molecular weight of IgG antibodies, the permeability of the blood-brain barrier is less important for detection of IgM antibodies in CSF than for IgG antibodies in CSF.…”

“…Symptoms such as headaches or radicular pain, as well as psychopatho-ACTA PfiDIATR SUPPL 386 [ 1993) logical disturbances which had persisted for weeks or had recurred intermittently disappeared after only a few days of high-dose penicillin treatments. This same effect was reported for adults with neuroborreliosis (168,235,290).…”