Cefazolin Induced Thrombocytopenia: A Rare Presentation

Abstract

Drug-induced immune thrombocytopenia is a frequent condition among hospitalized patients and is hard to diagnose because of the ambiguity of etiologies. It can lead to severe complications. We present a case of a 35-yearold male who was recently treated for infective endocarditis, now presenting with cellulitis. He was treated with cefazolin, a first-generation cephalosporin and later on developed severe thrombocytopenia. The diagnosis was difficult since our patient had multiple conditions that could explain his thrombocytopenia. This is one of the few reported cases of cefazolin-induced thrombocytopenia where we also discuss etiology, workup, and treatment in detail.