“…We found 18 perforations in patients not treated with IL-6 inhibitors. Of these 18 cases, 12 were lower GI perforations ( [1] , [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] ), 6 were perforated gastroduodenal ulcers ( 8 , [11] , [12] , [13] , [14] ). One of these after embolization of a bleeding ulcer ( 15 ).…”