cDNA Cloning of Human Allograft Inflammatory Factor-1: Tissue Distribution, Cytokine Induction, and mRNA Expression in Injured Rat Carotid Arteries

Autieri, Michael V.

doi:10.1006/bbrc.1996.1612

Cited by 97 publications

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“…11,12 In the current study, we extended this and showed that AIF-1 is expressed by vascular as well as inflammatory cells in injured human coronary arteries and correlates with PCNA expression. The most robust expression is localized to myofibroidlike SMC ␣-actin-positive cells in the neointima.…”

Section: Discussionsupporting

confidence: 68%

“…8 We have previously reported the acute and transient expression of AIF-1 in medial and intimal VSMC in several models of arterial injury in rat and swine. 11,12 Although constitutively expressed in leukocytes, AIF-1 is not expressed in unstimulated cultured human VSMC but is strongly induced in response to inflammatory cytokines and T-lymphocyte conditioned media. 12 We have also shown that overexpression of AIF-1 in VSMC leads to a more rapid growth and deregulated expression of cell cycle proteins, suggesting that one function of AIF-1 might be in the regulation of VSMC proliferation.…”

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confidence: 99%

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Allograft Inflammatory Factor-1 Expression Correlates With Cardiac Rejection and Development of Cardiac Allograft Vasculopathy

et al. 2002

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Background— Standard morphological features of endomyocardial biopsy specimens do not necessarily correlate with the efficacy of immunotherapy or development of cardiac allograft vasculopathy (CAV). We hypothesized that expression of allograft inflammatory factor-1 (AIF-1), a cytokine-inducible, calcium-binding protein associated with vascular smooth muscle cell proliferation, would be associated with allograft rejection and development of CAV. Methods and Results— A total of 157 endomyocardial biopsy specimens from 26 patients with heart transplants were examined for expression of AIF-1 mRNA by semiquantitative reverse transcription–polymerase chain reaction. A significant relation was found between the International Society for Heart and Lung Transplantation rejection grade and expression of AIF-1 ( P <0.001). The calculated odds ratio indicates that a biopsy has 2.5 times the chance of AIF-1 expression per grade of rejection. The relative concentrations of AIF-1 and GAPDH mRNA were calculated and the resulting ratios indicated that the amount of AIF-1 mRNA expression is relative to the rejection grade ( P <0.02). In grade 1 biopsy specimens, AIF-1 was localized to infiltrating immune cells. In grade 3 biopsy specimens, AIF-1 was observed in immune cells and myocytes. AIF-1 is expressed in vascular and immune cells in coronary arteries with CAV, and persistent expression of AIF-1 in the allograft correlates with development of CAV ( P <0.002). Conclusions— Expression of AIF-1 in cardiac allografts correlates with rejection, and the amount of AIF-1 expressed correlates with the severity of rejection. AIF-1 is expressed in coronary arteries with CAV, and persistent expression of AIF-1 in the cardiac allograft is associated with development of CAV.

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Section: Discussionsupporting

confidence: 68%

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confidence: 99%

Allograft Inflammatory Factor-1 Expression Correlates With Cardiac Rejection and Development of Cardiac Allograft Vasculopathy

et al. 2002

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“…The identified clam AIF-1 has 171 aa and more similar to the average size of AIF-1 family as described by Deininger et al (2002). Some conserved sequences and characteristic motifs were also found in the deduced amino acid sequence of VpAIF-1, such as AIF- In previous studies, AIF-1 had been described that it was expressed in muscle, liver, spleen and thymus in rat [19] and human [20], and was expressed in haemocyte, gill, mantle, muscle, digestive tract and hepatopancreas in disk abalone [13]. In the present study, we observed that ubiquitously expressed VpAIF-1 transcripts in a variety of unstimulated clam tissues, suggesting it could participate in various processes in manila clam V. philippinarum.…”

Section: Discussionmentioning

confidence: 51%

Cloning and characterization of allograft inflammatory factor-1 (AIF-1) from manila clam Venerupis philippinarum

Zhang

Zhao

et al. 2011

Fish & Shellfish Immunology

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“…Allograft inflammatory factor 1 (AIF-1) is a 17-kDa Ca 2+ -binding EF-hand intracellular protein that is encoded by the HLA class III genomic region (10)(11)(12). AIF-1 was originally cloned from activated macrophages in atherosclerotic allogenic heart grafts undergoing chronic immune rejection in a rat (13).…”

Section: Introductionmentioning

confidence: 99%

Allograft inflammatory factor-1 in the pathogenesis of bleomycin-induced acute lung injury

Nagahara

Yamamoto

Seno

et al. 2016

BST

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cDNA Cloning of Human Allograft Inflammatory Factor-1: Tissue Distribution, Cytokine Induction, and mRNA Expression in Injured Rat Carotid Arteries

Cited by 97 publications

References 0 publications

Allograft Inflammatory Factor-1 Expression Correlates With Cardiac Rejection and Development of Cardiac Allograft Vasculopathy

Allograft Inflammatory Factor-1 Expression Correlates With Cardiac Rejection and Development of Cardiac Allograft Vasculopathy

Cloning and characterization of allograft inflammatory factor-1 (AIF-1) from manila clam Venerupis philippinarum

Allograft inflammatory factor-1 in the pathogenesis of bleomycin-induced acute lung injury

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