cDNA Cloning and Expression of a Novel Adipose Specific Collagen-like Factor, apM1 (AdiposeMost Abundant Gene Transcript 1)

Maeda, Kazuhisa; Okubo, Kousaku; Shimomura, Iichiro; Funahashi, Tohru; Matsuzawa, Yūji; Matsubara, Kazuo

doi:10.1006/bbrc.1996.0587

Cited by 1,867 publications

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“…4,[25][26][27] Decreased adiponectin levels were described in weight-stable obese subjects. However, many studies have reported an association between obesity risk and hyperadiponectinemia associated with polymorphisms, 9,18,28 which were in accordance with our results.…”

Section: Discussionmentioning

confidence: 99%

Promoter adiponectin polymorphisms and waist/hip ratio variation in a prospective French adults study

et al. 2007

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Background: Adiponectin expression and plasma concentrations are decreased in human and animal models of obesity. Several single nucleotide polymorphisms (SNPs) in the adiponectin gene are known to influence the plasmatic concentration of the encoded protein. Some of these adiponectin polymorphisms have been associated with BMI in cross-sectional studies. Objective: The aim of our study was to examine the longitudinal relationships between adiponectin gene polymorphisms and anthropometric indices. Design: Two adiponectin gene (ADIPOQ) SNPs, À11391G4A and À11377C4G, were genotyped in 837 French Caucasian subjects from the SUpplémentation en VItamines et Minéraux Anti-oXydants (SU.VI.MAX) cohort. Anthropometric scores were measured at three clinical examinations over a 7-year period. Results: For À11391G4A as well as for À11377C4G, we detected no association between the variant allele and anthropometric measurements at baseline. Considering longitudinal effects, we detected moderately higher waist-to-hip ratio (WHR) changes for the carriers of the À11391A (P ¼ 0.02) and À11377C (P ¼ 0.03) allele over the follow-up of the study. À11391G4A and À11377C4G define haplotypes associated also with WHR measurements and their changes over the followup of the study. Diploid configurations that combine À11391A and À11377C were associated with significantly higher WHR changes (DCE: P ¼ 0.02) compared to other haplotypes. In addition, higher adiponectin levels were observed in AC/AC diplotypes compared to GG/GG carriers (Po0.0001). Conclusion: In the SU.VI.MAX study, genetic variations in the adiponectin gene affect abdominal fat gain over life span.

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Section: Discussionmentioning

confidence: 99%

Promoter adiponectin polymorphisms and waist/hip ratio variation in a prospective French adults study

et al. 2007

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“…Adiponectin was independently characterized in 1995 and 1996 by four groups using different methods, hence its alternative names of apM1 (adipose most abundant gene transcript 1), Acrp30 (adipocyte complement-related protein of 30 kDa), adipoQ, and GBP28 (gelatin binding protein of 28 kDa) (43)(44)(45)(46). Adiponectin is highly and specifically expressed in differentiated adipocytes and circulates at high levels in the bloodstream (47).…”

Section: Adiponectinmentioning

confidence: 99%

“…Adiponectin is an approximately 30-kDa polypeptide containing an Nterminal signal sequence, a variable domain, a collagen-like domain, and a C-terminal globular domain (43)(44)(45)(46). It shares strong sequence homology with type VIII and X collagen and complement component C1q (43)(44)(45)(46). Interestingly, the tertiary structure of the globular domain bears a striking similarity to TNF␣, despite a lack of homology in primary sequence (47).…”

Section: Adiponectinmentioning

confidence: 99%

Adipose Tissue as an Endocrine Organ

Ahima

Flier

2000

Trends in Endocrinology & Metabolism

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“…The adipocyte-derived hormone adiponectin (also known as Acrp30, GBP28 or AdipoQ) [1][2][3][4] has been shown to play important roles in the regulation of glucose and lipid metabolism. Plasma adiponectin levels are reduced in obese and insulin-resistant humans and in animal models [2,5,6].…”

Section: Introductionmentioning

confidence: 99%

Adiponectin induces insulin secretion in vitro and in vivo at a low glucose concentration

et al. 2008

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Aims/hypothesis A decrease in plasma adiponectin levels has been shown to contribute to the development of diabetes. However, it remains uncertain whether adiponectin plays a role in the regulation of insulin secretion. In this study, we investigated whether adiponectin may be involved in the regulation of insulin secretion in vivo and in vitro. Methods The effect of adiponectin on insulin secretion was measured in vitro and in vivo, along with the effects of adiponectin on ATP generation, membrane potentials, Ca 2+ currents, cytosolic calcium concentration and state of 5′-AMP-activated protein kinase (AMPK). In addition, insulin granule transport was measured by membrane capacitance and total internal reflection fluorescence (TIRF) analysis.Results Adiponectin significantly stimulated insulin secretion from pancreatic islets to approximately 2.3-fold the baseline value in the presence of a glucose concentration of 5.6 mmol/l. Although adiponectin had no effect on ATP generation, membrane potentials, Ca 2+ currents, cytosolic calcium concentrations or activation status of AMPK, it caused a significant increase of membrane capacitance to approximately 2.3-fold the baseline value. TIRF analysis revealed that adiponectin induced a significant increase in the number of fusion events in mouse pancreatic beta cells under 5.6 mmol/l glucose loading, without affecting the status of previously docked granules. Moreover, intravenous injection of adiponectin significantly increased insulin secretion to approximately 1.6-fold of baseline in C57BL/6 mice. Diabetologia (2008) Conclusions/interpretation The above results indicate that adiponectin induces insulin secretion in vitro and in vivo.

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cDNA Cloning and Expression of a Novel Adipose Specific Collagen-like Factor, apM1 (AdiposeMost Abundant Gene Transcript 1)

Cited by 1,867 publications

References 0 publications

Promoter adiponectin polymorphisms and waist/hip ratio variation in a prospective French adults study

Promoter adiponectin polymorphisms and waist/hip ratio variation in a prospective French adults study

Adipose Tissue as an Endocrine Organ

Adiponectin induces insulin secretion in vitro and in vivo at a low glucose concentration

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