Cdc25A phosphatase: a key cell cycle protein that regulates neuron death in disease and development

Biswas, Subhas C.; Sanphui, Priyankar; Chatterjee, Nandini; Kemeny, Stav; Greene, Lloyd A.

doi:10.1038/cddis.2017.115

Cited by 10 publications

(8 citation statements)

References 14 publications

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“…As mentioned in the literature, CDC25A dephosphorylates cyclin-dependent kinase and regulates the cell cycle in cell proliferation (Liang et al, 2016). In zebrafish, upon misexpression of CDC25A, several essential T -box transcription factors are abnormally expressed, which specifically prevents the normal onset of myoD transcription, leading to aberrant muscle formation (Bouldin et al, 2014). CDC25A can promote cell proliferation and osteoblast differentiation and ensure the health and genomic stability of the developing embryo (Verduzco et al, 2012;Qiu and Kassem, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…CDC25A is a member of the CDC25 family of phosphatases and also a dual-specificity protein phosphatase. Several literature studies have shown that CDC25A is one of the most crucial cell cycle regulators which is required for activation of the apoptotic cell cycle pathway (Shen and Huang, 2012;Biswas et al, 2017). In terms of embryos, promoting CDC25A expression can regulate cell proliferation and axis extension during gastrulation in zebrafish.…”

Section: Introductionmentioning

confidence: 99%

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A 20-bp insertion/deletion (indel) polymorphism within the CDC25A gene and its associations with growth traits in goat

et al. 2019

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Abstract. Cell division cycle 25A (CDC25A), a member of the CDC25 family of phosphatases, is required for progression from G1 to the S phase of the cell cycle. CDC25A provides an essential function during early embryonic development in mice, suggesting that it plays an important role in growth and development. In this study, we used mathematical expectation (ME) methods to identify a 20-bp insertion/deletion (indel) polymorphism of CDC25A gene in Shaanbei White Cashmere (SBWC) goats. We also investigated the association between this 20-bp indel and growth-related traits in SBWC goats. Association results showed that the indel was related to growth traits (height at hip cross, cannon circumference, and cannon circumference index) in SBWC goats. The height at hip cross of individuals with insertion/insertion (II) genotype was higher than those with insertion/deletion (ID) genotype (P=0.02); on the contrary, the cannon circumference and cannon circumference index of individuals with ID genotype were superior when compared with those with II genotype (P=0.017 and P=0.009). These findings suggest that the 20-bp indel in the CDC25A gene significantly affects growth-related traits, and could be utilized as a candidate marker for marker-assisted selection (MAS) in the cashmere goat industry.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A 20-bp insertion/deletion (indel) polymorphism within the CDC25A gene and its associations with growth traits in goat

et al. 2019

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“…Recently, several studies have reported that decreased CDC25A expression might inhibit malignant progression by suppressing cell-cycle pathway. 7,21,22 Similarly, CDC25A plays a unique role in activating cyclin B1-Cdk1 (CCNB1-CDK1) at the centrosome, 23 and is thought to be regulated by microRNA-99a-5p, miR-497 and miR-483-3p in cancer. 11,24,25 According to TCGA database analysis, CDC25A showed upregulation in GC, while down-regulation of CDC25A prolonged the survival period in GC.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, CDC25A is regarded as an oncogene, but its exact role in oncogenesis has not been demonstrated. 7 Aberrant CDC25A expression was associated with disease progression in GC, 8 skin cancer 9 and retinoblastoma. 10 The expression of CDC25A is downregulated by miR-497 in chondrosarcoma.…”

Section: Introductionmentioning

confidence: 99%

Circular RNA Profiling Reveals That circRNA_104433 Regulates Cell Growth by Targeting miR-497-5p in Gastric Cancer

Wei¹,

Mo²,

Yan³

et al. 2020

CMAR

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Background: The role and mechanism of hsa_circRNA_104433 in gastric cancer (GC) are further elucidated. Materials and methods: CircRNA_104433 was selected by circRNA microarrays and GEO database. qRT-PCR was used to analyze the expression of circRNA_104433 in GC. The role of circRNA_104433 in GC cells was evaluated based on cell cycle progression, cell proliferation, cell apoptosis, and tumor xenograft experiment assay. To explore the mechanisms of circRNA_104433 in GC TCGA database, STRING version, qRT-PCR and luciferase assay were performed. Furthermore, the prognostic value of CDC25A in GC was determined based on the GEO database. Results: The level of circRNA_104433 showed upregulation in GC tissues, and the expression of it showed a positive correlation with the degree of differentiation and the size of the tumor. Knockdown of circRNA_104433 inhibited cell cycle transition, and cell proliferation, while promoted cell apoptosis in GC. CircRNA_104433 directly binds to miR-497-5p, which directly regulates CDC25A. The median survival period of GC patients with high expression levels of CDC25A was 21.3 months, which was shorter than those with low group expression of CDC25A (35.9 months). The cell cycle proteins CDK1, CDK2, CCNB1, PKMYT1, CDC20, CHEK1 and CDC25A were coexpressed with CDC25A. Conclusion: These findings suggested that knockdown of circRNA_104433 expression suppressed tumor development in GC.

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“…Importantly, the direct targeting of cell cycle regulators by small molecules or by genetic perturbation has produced favorable results with regard to the suppression of pathologic neuron degeneration and tumorigenesis. However, these experiments were performed in vitro in mammalian tumor cell lines, or in vivo using genetically engineered disease models (Kar et al, 2006;Chatterjee et al, 2016;Biswas et al, 2017;Tomás-Loba et al, 2019). Therefore, the translation of basic research into clinical treatment remains a critical challenge.…”

Section: Discussionmentioning

confidence: 99%

Novel insights into cell cycle regulation of cell fate determination

Gao

Liu

2019

J. Zhejiang Univ. Sci. B

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The stem/progenitor cell has long been regarded as a central cell type in development, homeostasis, and regeneration, largely owing to its robust self-renewal and multilineage differentiation abilities. The balance between self-renewal and stem/progenitor cell differentiation requires the coordinated regulation of cell cycle progression and cell fate determination. Extensive studies have demonstrated that cell cycle states determine cell fates, because cells in different cell cycle states are characterized by distinct molecular features and functional outputs. Recent advances in high-resolution epigenome profiling, single-cell transcriptomics, and cell cycle reporter systems have provided novel insights into the cell cycle regulation of cell fate determination. Here, we review recent advances in cell cycle-dependent cell fate determination and functional heterogeneity, and the application of cell cycle manipulation for cell fate conversion. These findings will provide insight into our understanding of cell cycle regulation of cell fate determination in this field, and may facilitate its potential application in translational medicine.

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Cdc25A phosphatase: a key cell cycle protein that regulates neuron death in disease and development

Cited by 10 publications

References 14 publications

A 20-bp insertion/deletion (indel) polymorphism within the <i>CDC25A</i> gene and its associations with growth traits in goat

A 20-bp insertion/deletion (indel) polymorphism within the <i>CDC25A</i> gene and its associations with growth traits in goat

<p>Circular RNA Profiling Reveals That circRNA_104433 Regulates Cell Growth by Targeting miR-497-5p in Gastric Cancer</p>

Novel insights into cell cycle regulation of cell fate determination

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Cdc25A phosphatase: a key cell cycle protein that regulates neuron death in disease and development

Cited by 10 publications

References 14 publications

A 20-bp insertion/deletion (indel) polymorphism within the &lt;i&gt;CDC25A&lt;/i&gt; gene and its associations with growth traits in goat

A 20-bp insertion/deletion (indel) polymorphism within the &lt;i&gt;CDC25A&lt;/i&gt; gene and its associations with growth traits in goat

<p>Circular RNA Profiling Reveals That circRNA_104433 Regulates Cell Growth by Targeting miR-497-5p in Gastric Cancer</p>

Novel insights into cell cycle regulation of cell fate determination

Contact Info

Product

Resources

About

A 20-bp insertion/deletion (indel) polymorphism within the <i>CDC25A</i> gene and its associations with growth traits in goat

A 20-bp insertion/deletion (indel) polymorphism within the <i>CDC25A</i> gene and its associations with growth traits in goat