2000
DOI: 10.1093/emboj/19.19.5123
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Abstract: contributed equally to this work CD95 (APO-1/Fas) is a member of the tumor necrosis factor receptor family, which can trigger apoptosis in a variety of cell types. However, little is known of the mechanisms underlying cell susceptibility to CD95-mediated apoptosis. Here we show that human T cells that are susceptible to CD95-mediated apoptosis, exhibit a constitutive polarized morphology, and that CD95 colocalizes with ezrin at the site of cellular polarization. In fact, CD95 co-immunoprecipitates with ezrin e… Show more

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Cited by 196 publications
(232 citation statements)
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“…In this study, the downregulation of ezrin did not affect cell death in CEM cells triggered by FasL or CH11 (Supplementary Figure 2b, data not shown for CH11). Contrary to the reports that ezrin reduction impaired Fas-induced apoptosis (Parlato et al, 2000;He´bert et al, 2008), Fas-mediated apoptosis was not affected in Jurkat and CEM cells that were deficient in ezrin. In a separated experiment, overexpression of wild-type ezrin in Jurkat cells did not affect FasL-triggered apoptosis (Supplementary Figures 1c and d).…”
Section: Enhanced Apoptosis In H9 Cells Expressing Ezrin Dominant-negcontrasting
confidence: 99%
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“…In this study, the downregulation of ezrin did not affect cell death in CEM cells triggered by FasL or CH11 (Supplementary Figure 2b, data not shown for CH11). Contrary to the reports that ezrin reduction impaired Fas-induced apoptosis (Parlato et al, 2000;He´bert et al, 2008), Fas-mediated apoptosis was not affected in Jurkat and CEM cells that were deficient in ezrin. In a separated experiment, overexpression of wild-type ezrin in Jurkat cells did not affect FasL-triggered apoptosis (Supplementary Figures 1c and d).…”
Section: Enhanced Apoptosis In H9 Cells Expressing Ezrin Dominant-negcontrasting
confidence: 99%
“…Similar to previous reports (Parlato et al, 2000;Lozupone et al, 2004), recombinant ezrin bound directly to Fas in a glutathione S-transferase (GST) pull-down assay (Figure 1a). The association of ezrin with Fas during the course of Fas-mediated apoptosis was also monitored in H9 cells, a type I cell line known for prominent DISC formation (Scaffidi et al, 1998;Algeciras-Schimnich et al, 2002;Lee et al, 2006).…”
Section: Dissociation Of Ezrin From Death Receptor After Fas Ligand (supporting
confidence: 87%
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