CD8+ cutaneous T-cell lymphoma with pagetoid epidermotropism and angiocentric and angiodestructive infiltration

Junctional CD8+ Cutaneous Lymphomas With Nonaggressive Clinical Behavior

“…[5][6][7] The primary cutaneous lymphomas with the phenotype of cytotoxic/ suppressor (CD8 + ) T cells have been of significant interest in the recent literature. [8][9][10][11][12] The detailed analysis of histological and clinical features in several cases has led to the conclusion that CD8 + T-cell lymphomas represent a distinct type of CTCL with an aggressive clinical behavior. 4,12 Within the last 3 years, we have seen 3 cases that have fulfilled the criteria of an CD8 + epidermotropic T-cell lymphoma with a remarkable affinity of the CD8 + cells to the dermoepidermal junction zone.…”

CD8+ cutaneous T‐cell lymphoma successfully treated with bexarotene: A case report and review of the literature

“…Similar to its more common CD41 counterpart, CD81 CTCL can present in many different clinical patterns with advancing stage inversely correlating with prognosis. Two distinct subgroups of CD81 CTCL have been recognized [3,[11][12][13][14][19][20][21][22][23][24][25][26]. One, as is exemplified by the case presented herein, clinically behaves very similar to that of CD41 CTCL with a rather indolent course and response to a variety of local and systemic therapies.…”

I double dare me

“…If I suspect hypopigmented MF in a child or if there is conspicuous epidermotropism, as has been associated with a CD8-positive immunophenotype, perhaps I will occasionally add CD4 and CD8 stains as an additional step in assessment. 10,11 I will skip the CD20 and the CD7, as their potential for impacting my diagnosis is slim. I double dare me.…”